Anne Briançon‐Marjollet

PCSK9 as a mediator of monocytes transendothelial activation in obstructive sleep apnoea: A translational study

Marc-Adrien Reveyaz, Yann Sibaud, Maël Brossette, Alejandro Arco-Hierves et autres

Obstructive sleep apnoea (OSA) causes intermittent hypoxia (IH) during sleep which is the main trigger for associated cardiovascular complications. IH increases endothelial permeability and vascular remodelling. The proprotein convertase subtilisine kexine type 9 (PCSK9) is capable of promoting vascular inflammation. This study …

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Sex-dependent effect of anti-PCSK9 treatment in mice aorta

Marc-Adrien Reveyaz, Yann Sibaud, Esteban Liégeois, Guillaume Vial et autres

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Impact du sexe sur les phénotypes de syndrome d’apnées du sommeil post-AVC : une étude de cohorte clinique

Tiffanie Joubert, Mélanie Minovès, Elodie Gautier‐Veyret, Loïc Legris et autres

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Rôle de PCSK9 dans les altérations vasculaires induites par l’hypoxie intermittente

Marc-Adrien Reveyaz, Alejandro Arco-Hierves, Antoine Boutin-Paradis, Van Ngo et autres

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Apnées du sommeil après un accident vasculaire cérébral : impact de l’hypoxie intermittente sur la récupération cérébrovasculaire

Bayan El Amine, Aurélien Delphin, Marc-Adrien Reveyaz, Nora Collomb et autres

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Intermittent Hypoxia Alters Cerebrovascular Recovery After Stroke

Bayan El Amine, Aurélien Delphin, Marc-Adrien Reveyaz, Célian Peyronnel et autres

Abstract Stroke is a prevalent chronic disease, significantly contributing to mortality and long-term disability. The cerebrovascular recovery process after stroke can be complicated by certain comorbidities, including obstructive sleep apnea syndrome (OSA). However, the mechanisms underlying this deleterious impact of OSA on …

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Oxidative and Inflammatory Mechanisms Induced by Intermittent Hypoxia Leading to Vascular Alterations in Rodents: A Systematic Review and Meta‐Analysis

Marc-Adrien Reveyaz, Célian Peyronnel, Quentin Boëté, Joey Fournier et autres

Objectives Obstructive sleep apnea (OSA) and the related intermittent hypoxia (IH) are recognized as major cardiovascular risk factors. In a previous meta‐analysis, we confirmed the impact of IH on structural and functional remodeling of vessels in rodent models of IH. Here, we …

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Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling

Bayan El Amine, Benjamin Lemasson, Aurélien Delphin, Marc-Adrien Reveyaz et autres

Abstract Background Ischemic stroke is a leading cause of mortality and disability worldwide, yet therapeutic options remain limited. Preclinical models play a crucial role in understanding stroke pathophysiology and evaluating potential treatments. This study aimed to provide a comprehensive characterization of the …

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Impact Of Obstructive Sleep Apnoea and Its Severity On The Mechanisms Of Aortic Valve Atherosclerosis

Perrine Petit, Emeline Lemarié, Marie Destors, Sébastien Baillieul et autres

Obstructive sleep apnoea (OSA) is a common chronic condition associated with cardiovascular disease including calcific aortic valve disease (CAVD). The aim of this study was to assess the impact of OSA on mechanisms of atherosclerosis involved in CAVD, particularly autophagy, inflammation, oxidative …

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PCSK9 as a new player in intermittent hypoxia-induced vascular alterations

Marc-Adrien Reveyaz, Alejandro Arco-Hierves, Antoine Boutin-Paradis, Renaud Tamisier et autres

Obstructive sleep apnea (OSA) causes nocturnal episodes of intermittent hypoxia (IH) and major cardiovascular complications. IH increases endothelial permeability and vascular remodeling. The proprotein convertase subtilisine kexine type 9 (PCSK9) has inflammatory effects on arteries. This study aims at characterizing PCSK9 expression …

fr (code pays fourni par la source)

Post-stroke sleep apnea: the effect of intermittent hypoxia on cerebrovascular recovery

Anne Briançon‐Marjollet, Bayan El Amine, Benjamin Lemasson, Marc-Adrien Reveyaz et autres

Introduction: Ischemic stroke is the death of brain cells due to lack of oxygen caused by blockage of blood flow. Stroke is associated with decline in cognitive function. The cerebrovascular recovery process can be complicated by certain comorbidities, including obstructive sleep apnea …

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PCSK9 as a new player in intermittent hypoxia-induced vascular alterations

Marc-Adrien Reveyaz, Alejandro Arco Hierves, Antoine Boutin-Paradis, Renaud Tamisier et autres

fr (code pays fourni par la source)