Paul Jülicher

Cost-effectiveness of applying high-sensitivity troponin I to a score for cardiovascular risk prediction in asymptomatic population

Paul Jülicher, Nataliya Makarova, Francisco Ojeda, Isabella Giusepi et autres

INTRODUCTION: Risk stratification scores such as the European Systematic COronary Risk Evaluation (SCORE) are used to guide individuals on cardiovascular disease (CVD) prevention. Adding high-sensitivity troponin I (hsTnI) to such risk scores has the potential to improve accuracy of CVD prediction. We …

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A cost-effectiveness evaluation of a high-sensitivity troponin I guided voluntary cardiovascular risk assessment program for asymptomatic women in Croatia

Goran Krstačić, Paul Jülicher, Antonija Krstačić, Christos Varounis

Background: To estimate the effectiveness and cost-effectiveness of a high-sensitivity troponin I (hsTnI) guided cardiovascular risk assessment program in women in Croatia. Methods: An observational study of a voluntary program for cardiovascular disease (CVD) risk assessment in women aged above 45 years …

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Improved implementation of medical tests – barriers and opportunities

Andrew St John, Maurice O’Kane, Paul Jülicher, Christopher P. Price

Applying the concept of a value proposition to medical testing is just one of the many ways to identify and monitor the value of tests. A key part of this concept focusses on processes that should take place after a test is …

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Implementation of medical tests in a Value-Based healthcare environment: A framework for delivering value

Andrew St John, Maurice O’Kane, Robert H. Christenson, Paul Jülicher et autres

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Health economic evaluations of medical tests: Translating laboratory information into value – A case study example

Paul Jülicher, Maurice O’Kane, Christopher P. Price, Robert H. Christenson et autres

Health-care providers and funders are focused on identifying value in all their services and that includes laboratories. This means that in order to gain a share of scarce resources, laboratory professionals must also understand and assess the value of tests and that …

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Estimating the cost-effectiveness of screening a general population for cardiovascular risk with high-sensitivity troponin-I

Paul Jülicher, Christos Varounis

AIMS: To estimate the cost-effectiveness of using the cardiac specific marker high-sensitivity troponin-I (hsTnI) for assessing cardiovascular disease (CVD) risk in a general population. METHODS AND RESULTS: A discrete-event simulation model was developed from a societal perspective of a low-risk (Germany) and …

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Who Conducts Health Economic Evaluations of Laboratory Tests? A Scoping Review

Isabella Giusepi, Andrew St John, Paul Jülicher

BACKGROUND: Health economic evaluations (HEEs) are effectively used to inform decision making in healthcare. We sought to assess the level of involvement of laboratory professionals (LPs) in HEEs of laboratory tests. METHODS: A systematic literature search was conducted in Medline (2013 to …

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A value proposition for natriuretic peptide measurement in the assessment of patients with suspected acute heart failure

Maurice O’Kane, David Porter, Michael McCann, Paul Jülicher et autres

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Streamlining the screening cascade for active Hepatitis C in Russia: A cost-effectiveness analysis

Paul Jülicher, Vladimir Chulanov, Nikolay Pimenov, Anna Yankina et autres

OBJECTIVE: Screening for hepatitis C in Russia is a complex process that involves several visits and stepwise testing, limiting adherence and substantially reducing the yield in the identification of active infections. We aimed to evaluate the cost-effectiveness of different screening algorithms from …

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HCV core antigen comes of age: a new opportunity for the diagnosis of hepatitis C virus infection

Claudio Galli, Paul Jülicher, Mario Plebani

The diagnosis of hepatitis C virus (HCV) infection has been traditionally based on the detection of the host antibody response. Although antibody assays are available in different formats and are fairly accurate, they cannot distinguish between an ongoing infection with HCV replicative …

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Developing a value proposition for high-sensitivity troponin testing

Andrew St John, Louise Cullen, Paul Jülicher, Christopher P. Price

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Identifying cost-effective screening algorithms for active hepatitis C virus infections in a high prevalence setting

Paul Jülicher, Claudio Galli

OBJECTIVE: To evaluate the cost-effectiveness of different screening patterns for active chronic hepatitis C virus (HCV) infections utilizing the hepatitis C core antigen test compared to standard care in the context of a general screening program in a high-prevalence country. METHODS: This …

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