Fabio Mele

Case Report: Long-term maternal and neonatal outcomes after nivolumab therapy in metastatic tonsillar sarcomatoid squamous cell carcinoma

Elisabetta Guida, Benedetta Apollonio, Chiara Bungaro, Fabio Mele et autres

Background: Immunotherapy with checkpoint inhibitor (ICI) has revolutionized the treatment of cancer including squamous cell carcinoma. Nevertheless, there is an unmet need to gain a better understanding of the effect of these therapies on pregnancy and fertility. Treatment with anti-PD-1 therapy decreases …

it (code pays fourni par la source)

An artificial intelligence-based model exploiting H&E images to predict recurrence in negative sentinel lymph-node melanoma patients

Maria Colomba Comes, Livia Fucci, Sabino Strippoli, Samantha Bove et autres

BACKGROUND: Risk stratification and treatment benefit prediction models are urgent to improve negative sentinel lymph node (SLN-) melanoma patient selection, thus avoiding costly and toxic treatments in patients at low risk of recurrence. To this end, the application of artificial intelligence (AI) …

it (code pays fourni par la source)

A deep learning model based on whole slide images to predict disease-free survival in cutaneous melanoma patients

Maria Colomba Comes, Livia Fucci, Fabio Mele, Samantha Bove et autres

The application of deep learning on whole-slide histological images (WSIs) can reveal insights for clinical and basic tumor science investigations. Finding quantitative imaging biomarkers from WSIs directly for the prediction of disease-free survival (DFS) in stage I-III melanoma patients is crucial to …

it (code pays fourni par la source)

1281 Recurrence prediction in cutaneous melanoma patients by exploiting deep learning on H&E slide images

Michele Guida, Maria Colomba Comes, Livia Fucci, Sabino Strippoli et autres

Background Cutaneous melanoma is one of the most aggressive forms of skin cancer with a high mortality rate.1 A prognosis improvement in cutaneous melanoma patients is crucial to better plan personalized treatments. Currently, clinical prognosis methods for the evaluation of the risk …

it (code pays fourni par la source)

Cemiplimab in an Elderly Frail Population of Patients With Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma: A Single-Center Real-Life Experience From Italy

Sabino Strippoli, Annarita Fanizzi, Davide Quaresmini, Annalisa Nardone et autres

BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer whose incidence is growing parallel to the lengthening of the average lifespan. Cemiplimab, an antiPD-1 monoclonal antibody, is the first approved immunotherapy for patients with locally advanced CSCC (laCSCC) …

it (code pays fourni par la source)

Cryopreservation of adipose tissue with and without cryoprotective agent addition for breast lipofilling: A cytological and histological study

Grace Massiah, Giuseppe De Palma, Antonio Negri, Fabio Mele et autres

In the second reconstructive phase of the breast after mastectomy, lipofilling is often necessary. Currently, lipofilling occurs immediately after autologous adipose tissue harvesting procedure, but most of the patients, usually, require multiple sessions to obtain a satisfactory result. Therefore, the need of …

it (code pays fourni par la source)

The role of rapid on site evaluation on touch imprint cytology and brushing during conventional bronchoscopy

Maria Antonietta Botticella, Simona De Summa, Luigi Cisternino, Stefania Tommasi et autres

BACKGROUND: The increase in immunohistochemical and molecular predictive tests in lung cancer requires new strategies for managing small samples taken during bronchoscopic procedures. The value of Rapid On Site Evaluation (ROSE) during conventional bronchoscopic procedures on endobronchial neoplasms in optimizing small biopsies …

it (code pays fourni par la source)

BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients

Umberto Malapelle, Giulio Rossi, Pasquale Pisapia, Massimo C.P. Barberis et autres

it (code pays fourni par la source)

Pulmonary enteric adenocarcinoma: an overview

Raffaele Palmirotta, Domenica Lovero, Stella D’Oronzo, Valeria Internò et autres

Most commonly described as sporadic, pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare variant of invasive lung cancer recently established and recognised by the World Health Organization. This tumour is highly heterogeneous and shares several morphological features with pulmonary and colorectal …

it (code pays fourni par la source)

The Management of Oligoprogression in the Landscape of New Therapies for Metastatic Melanoma

Michele Guida, Nicola Bartolomeo, Ivana De Risi, Livia Fucci et autres

Background: A limited degree of progression after a response to treatment is labelled as oligoprogression and is a hot topic of metastatic melanoma (MM) management. Rogue progressive metastases could benefit from local treatment, which could allow the continuation of ongoing systemic therapy, …

it, cn (code pays fourni par la source)

Cutaneous metastasis as a primary presentation of a pulmonary enteric adenocarcinoma

Valeria Internò, Luigia Stefania Stucci, Carmela Ostuni, Domenica Lovero et autres

Background: Primary pulmonary enteric adenocarcinoma (PEAC) is a rare non-small cell lung cancer subtype sharing morphologic and immunohistochemical features with colorectal adenocarcinoma. Given the frequency of lung metastases in colorectal cancer, the differential diagnosis of PEAC according to routine morphological and immunohistochemical …

it (code pays fourni par la source)

Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable to formalin-fixed paraffin-embedded tissue

Sabino Ciavarella, M.C. Vegliante, Marco Fabbri, Simona De Summa et autres

Ann Oncol 2018; 29: 2363–2370 (doi: 10.1093/annonc/mdy450) The affiliations of authors T. Venesio and A. Sapino were originally incorrect. These have now been corrected as per the author listing above. Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable …

it, es (code pays fourni par la source)