Barbara Krystyna Pierscionek

Design and Development of Dry Powder Cyclodextrin Complexes of Zinc Diethyldithiocarbamate for Pulmonary Drug Delivery

Ayşe Kaya, Basel Arafat, Havovi Chichger, Barbara Krystyna Pierscionek et autres

Background: Pulmonary drug delivery represents a promising approach for the potential localised treatment of respiratory of non-small-cell lung cancer (NSCLC). However, the efficient delivery of poorly water-soluble drugs remains challenging due to limited solubility and inadequate aerodynamic performance. This study aimed to …

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What is ‘eye stroke’ and why has it been linked to weight loss injections?

Barbara Krystyna Pierscionek

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A digital twin framework for predicting and simulating type 2 diabetes onset using retrospective lifestyle data

Mahreen Kiran, Ying Xie, Graham Ball, Rudolph Schutte et autres

Introduction: Type 2 Diabetes Mellitus (T2DM) is a rising global health concern, heavily influenced by modifiable lifestyle and psychosocial factors. However, most predictive tools focus on biomedical markers and rely on real-time data from wearables or electronic health records, limiting their scalability …

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Lens shape change is influenced by zonular anchorage and stretching mechanism

Yutian Pu, Chunjing Tao, Barbara Krystyna Pierscionek, Kehao Wang

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Review on the utility of artificial intelligence in robotic surgery

Çağatay TAŞDEMİRCİ, M. Ashfaqul Alam, Richard A. Jones, Barbara Krystyna Pierscionek

ABSTRACT The integration of Artificial Intelligence (AI) in robotic surgery has the potential to revolutionize the field. Early in the surgical journey, AI-assisted operative planning can improve the precision and success of interventions. Additionally, AI-supported intraoperative image processing enhances the detection and …

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Refractive index gradient in the lens: reflections on form and function and on the lens paradox

Barbara Krystyna Pierscionek

Introduction The eye lens is a sophisticated optical element that provides the eye with both refractive power and transparency as well as the ability to change focus. The latter function diminishes with age as the lens becomes less able to change its …

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Roadmap on advances in visual and physiological optics

Jesús Emmanuel Gómez-Correa, Brian Vohnsen, Barbara Krystyna Pierscionek, Sabino Chávez Cerda et autres

The field of visual and physiological optics is undergoing continuous significant advancements, driven by a deeper understanding of the human visual system and the development of cutting-edge optical technologies. This Roadmap, authored by leading experts, delves into critical areas such as corneal …

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Eph-ephrin signaling affects lens growth and shape, nucleus size, and gradient refractive index in adult mice

Gryffin M. Flowers, Kehao Wang, Masato Hoshino, Kentaro Uesugi et autres

Purpose The function of the eye lens, to fine focus light from different distances onto the retina to form a clear image, relies on tissue biomechanical properties, refractive index, shape, and transparency. Increased lens stiffness with age, especially of the center or …

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Correction: Dumbuya et al. Exploring Disulfiram’s Anticancer Potential: PLGA Nano-Carriers for Prolonged Drug Delivery and Potential Improved Therapeutic Efficacy. Nanomaterials 2024, 14, 1133

Ibrahim Dumbuya, Ana Maria Pereira, Ibrahim Tolaymat, Adnan Al Dalaty et autres

In the original publication [...].

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Human iPSC-Derived Lens Organoids Recapitulate Lens Development and Morphogenesis In Vitro

John T. Harrington, Robert D. Young, LI Xiu-jun, Ryuhei Hayashi et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.

Investigating the effect of capsular thickness and material properties on biomechanical and optical parameters in eye models

Ye Lin, Kehao Wang, Barbara Krystyna Pierscionek

The mechanism of accommodation, which defines the shape change of the eye lens in order to provide clear focus over a range of distances, is still not fully understood. The uncertainties in understanding pose an obstacle to comprehending the causal factors in …

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Central optical power of the isolated human lens without zonular tension

Ronald A. Schachar, Ira H. Schachar, Shubham Kumar, Farhad A. Kamangar et autres

The ability to focus at near is achieved by dynamic changes in the shape of the lens of the eye. The Helmholtz hypothesis of accommodation proposes that, at distance gaze, all of the lenticular supporting zonules are at maximal tension. To bring …

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