Jan van Amsterdam

Enhanced and Prolonged Euphoria during Co-Use of Alcohol and Cocaine: A Narrative and Integrative Review

Jan van Amsterdam, Wim van den Brink

INTRODUCTION: Alcohol and cocaine are frequently used simultaneously, with alcohol typically consumed prior to cocaine. Qualitative studies indicate that this combination enhances and prolongs euphoria compared to cocaine alone. The aim of this study was to collect quantitative data that were published …

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Sweet Flavors and the Addictive Potential of E-Cigarettes: A Systematic Narrative Review

Jan van Amsterdam, Wim van den Brink

INTRODUCTION: Population-based surveys indicate that sweet and fruity flavors in the e-liquids are key drivers of attractiveness of e-cigarettes (ECIGs). However, their role in the addictive potential of ECIGs is less well established. This systematic review aimed to synthetize the available evidence …

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Appearance of 2-MMC and 3-MMC on the illicit drug market in the Netherlands: A systematic narrative review of the prevalence and risks

Jan van Amsterdam, Ton Nabben, Wim van den Brink

BACKGROUND AND AIMS: Use of the synthetic methylmethcathinones 2-MMC and 3-MMC (2/3-MMC) is emerging, especially among young people, but their health risks remain unclear. METHOD: A systematic narrative review was conducted on studies describing the availability, pharmaco-toxicological profile, and user characteristics of …

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Explaining increased efficacy of naltrexone in the treatment of alcohol dependent patients with a family history of alcohol use disorder: A systematic review on the role of reward sensitivity and sweet liking

Jan van Amsterdam, Wim van den Brink

A positive family history of alcohol use disorder (FHA+) is one of the strongest risk factors for developing alcohol use disorder (AUD) compared. Importantly, naltrexone (NTX) has shown higher efficacy in treating FHA+ AUD patients than FHA− AUD patients. Possibly, this may …

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Designer benzodiazepines: Availability, motives, and fatalities. A systematic narrative review of human studies

Jan van Amsterdam, Wim van den Brink

BACKGROUND: Studies on illegal drug use often include the use of regular benzodiazepines (BZDs), i.e., BZDs of pharmaceutical quality, obtained either via diversion or prescription. However, since two decades, designer benzodiazepines (DBZDs) are emerging on the illicit drug markets. DBZDs are generally …

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Pharmacological perspectives and clinical applications in substance use disorders in adolescents

Jan van Amsterdam, Wim van den Brink

1. Adolescence is a key period in the development of alcohol and substance use and misuse. Starting in adolescence, many individuals experiment with the use of tobacco, alcohol and – to a lesser ex...

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Sweet-liking and sugar supplementation as innovative components in substance use disorder treatment: A systematic review

Jan van Amsterdam, Wim van den Brink

OBJECTIVE: Substance use disorders are a major global public health concern. While a wide range of psychotherapies and pharmacotherapies are available for their treatment, efficacy is limited and many patients fail to benefit from these treatments. Like addictive substances, sugar seems to …

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Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?

Tibor M. Brunt, Wim van den Brink, Jan van Amsterdam

Abstract Nitrous oxide (N2O), used medically as an anaesthetic, has gained popularity as a recreational drug, with rising prevalence particularly among young adults. While its reinforcing and addictive potential remains debated, N2O is proven to be neurotoxic, especially with prolonged, heavy use, …

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Challenges and support needs among persons with a migration background who use drugs in four European metropolitan cities

Aline Pouille, Clara De Ruysscher, Lena van Selm, Jan van Amsterdam et autres

BACKGROUND: Persons who migrate for economic reasons, along with asylum seekers and refugees, face multiple personal experiences and societal inequalities that increase the risk of mental health problems and substance dependency, compounded by intersectional social and economic vulnerabilities. The precarious situation and …

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Cannabis Use Variations and Myocardial Infarction: A Systematic Review

Jan van Amsterdam, Wim van den Brink

Background: Cannabis use is associated with an increased risk of coronary heart disease (CHD), including angina pectoris (AP), and myocardial infarction (MI). However, it is not clear whether cannabis use is an independent risk factor of AP and/or MI, because cannabis is …

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Challenges and support needs among persons with a migration background who use drugs in four European metropolitan cities

Aline Pouille, Clara De Ruysscher, Lena van Selm, Jan van Amsterdam et autres

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Explaining the high mortality among opioid-cocaine co-users compared to opioid-only users. A systematic review

Jan van Amsterdam, Wim van den Brink

RATIONALE: The opioid crisis in North America has recently seen a fourth wave, which is dominated by drug-related deaths due to the combined use of illicitly manufactured fentanyl [IMF] and stimulants such as cocaine and methamphetamine. OBJECTIVES: A systematic review addressing the …

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