Nicole Bradley

Dextrose with Insulin During Neonatal Resuscitation for Prolonged Asphyxia in a Near-Term Ovine Model: A Proof-of-Concept Study

Praveen Kumar Chandrasekharan, Arun Prasath, Sylvia F. Gugino, Justin Helman et autres

Background: Neonatal myocytes rely predominantly on glycolytic metabolism for survival during hypoxic conditions. During asphyxia, metabolic pathway dysregulation impairs cardiac myocyte contractility. Co-administration of dextrose and insulin may help restore metabolic homeostasis and improve cardiac function. Methods: Following blinded randomization and instrumentation, …

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Optimal Duration of Umbilical Cord Clamping with Ventilation in a Preterm Asphyxiated Ovine Model

Mausma Bawa, Sylvia F. Gugino, Justin Helman, Nicole Bradley et autres

Background: There is inadequate evidence to support recommendations for the delayed clamping of umbilical cords in preterm neonates who are born non-vigorous. Objective: In a preterm bradycardic ovine model, our objective was to compare the effects of early cord clamping with ventilation …

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Correction: Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study

Hamza Abbasi, Clariss Blanco, Arun Prasath, Mary Divya Kasu et autres

Authors and Affiliations John R. Oishei Children’s Hospital, Neonatology Department, Buffalo, NY, USA Hamza Abbasi, Clariss Blanco, Arun Prasath, Mary Kasu, Praveen Chandrasekharan & Munmun Rawat State University of New York at Buffalo, Buffalo, NY, USA Hamza Abbasi, Clariss Blanco, Arun Prasath, …

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Neonatal resuscitation for bradycardia (HR < 60 bpm)—an alternate approach using an ovine model

Mausma Bawa, Sylvia F. Gugino, Justin Helman, Nicole Bradley et autres

Abstract Background The International Liaison Committee on Resuscitation recommends initiating chest compressions (CC) in newborns when heart rate (HR) is <60 beats per minute (bpm) after 30 s of effective positive pressure ventilation (PPV). Methods Near-term lambs with asphyxia induced bradycardia (HR …

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The Utility of Umbilical Cord Pulse Oximetry—A Translational Study with Four Minutes of Deferred Cord Clamping Using an Asphyxiated Preterm Ovine Model

Justin Helman, Mausma Bawa, Sylvia F. Gugino, Nicole Bradley et autres

Background: Expert guidelines recommend using pulse oximetry (PO) in the delivery room to monitor oxygen saturation (SpO2) and heart rate (HR). Umbilical cord pulse oximetry (UCP) is a novel concept that, despite being postductal, could provide accurate measurements of SpO2 and HR, …

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Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study

Hamza Abbasi, Clariss Blanco, Arun Prasath, Mary Divya Kasu et autres

BACKGROUND: The efficacy of Laryngeal Mask Airway (LMA) epinephrine during neonatal resuscitation has not been studied. We hypothesize that LMA epinephrine is as effective as endotracheal tube (ETT) epinephrine. METHODS: Sixteen fetal lambs were randomized in ETT or LMA group for ventilation …

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Initial Use of 100% but Not 60% or 30% Oxygen Achieved a Target Heart Rate of 100 bpm and Preductal Saturations of 80% Faster in a Bradycardic Preterm Model

Mausma Bawa, Sylvia F. Gugino, Justin Helman, Lori C. Nielsen et autres

Background: Currently, 21−30% supplemental oxygen is recommended during resuscitation of preterm neonates. Recent studies have shown that 58% of infants < 32 week gestation age are born with a heart rate (HR) < 100 bpm. Prolonged bradycardia with the inability to achieve …

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Placental transfusion during neonatal resuscitation in an asphyxiated preterm model

Praveen Kumar Chandrasekharan, Sylvia F. Gugino, Carmon Koenigsknecht, Justin Helman et autres

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Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model

Praveen Kumar Chandrasekharan, Sylvia F. Gugino, Justin Helman, Carmon Koenigsknecht et autres

(1) Background: Optimal initial oxygen (O2) concentration in preterm neonates is controversial. Our objectives were to compare the effect of delayed cord clamping with ventilation (DCCV) to early cord clamping followed by ventilation (ECCV) on O2 exposure, gas exchange, and hemodynamics in …

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VO2max during successive maximal efforts

Carl Foster, Erin E. Kuffel, Nicole Bradley, Rebecca A. Battista et autres

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