Yi Feng

Clinical characteristics, surgical pathways, and outcomes of upper tract urothelial carcinoma with venous tumor thrombus: a multicenter retrospective study with a predominantly robotic approach

Qiang Cheng, Lu Yin, Zexuan Lv, Bin Jiang et autres

Upper tract urothelial carcinoma (UTUC) with venous tumor thrombus is exceedingly rare and highly aggressive, and its anatomical complexity poses major surgical challenges in the absence of standardized operative strategies. We retrospectively reviewed UTUC patients who underwent radical nephroureterectomy with thrombectomy at …

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Global trends in breast cancer bone metastasis research (2009–2024): a bibliometric and visual analysis of hotspots and future directions

Zhichao Wang, Yin Zuo, Xinyu Chen, Yongchun Pan et autres

BACKGROUND: Breast cancer bone metastasis (BCBM) is a prevalent complication with significant impact on patient survival and quality of life. Understanding the research landscape is crucial for guiding future studies. This bibliometric analysis aims to visualize and analyze global research trends in …

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Efficacy and Safety of Transapical Beating-Heart Myectomy in Patients Aged >65 Years With Hypertrophic Obstructive Cardiomyopathy

Xiantao Ma, Cai Cheng, Chenhe Li, Ningxin Hou et autres

BACKGROUND: Although septal myectomy remains the gold standard for drug-refractory hypertrophic obstructive cardiomyopathy, its application in older adult patients (aged ≥65 years) has been limited by technical complexity. This retrospective cohort study evaluated the safety and efficacy of transapical beating-heart septal myectomy …

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Intraoperative imaging of a combined minimally invasive therapy for aortic valve stenosis with hypertrophic obstructive cardiomyopathy: a case report

Xiaoxue Zhang, Shiliang Li, Zijun Chen, Yi Feng et autres

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Parvovirus B19–induced aplastic anemia following mechanical valve replacement

Xiantao Ma, Ningxin Hou, Chenhe Li, Yi Feng et autres

Human parvovirus B19 infection in immunocompetent adults predominantly manifests as arthropathy or erythema infectiosum, with transient aplastic crisis being a rare hematological complication. We report a diagnostically challenging case of a man in his late 40s who developed recurrent severe aplastic anemia …

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Exploring mitochondrial health and transplantation strategies in DCD heart transplantation: a systematic review

Xiaoxue Zhang, Yujie Yang, Huan Wang, Chenxi Yan et autres

This review explores the significant potential of mitochondrial transplantation (MT) in enhancing outcomes for DCD heart transplantation, particularly in mitigating ischemia-reperfusion injury (IRI). MT restores mitochondrial function and ATP production, thereby improving myocardial contractility and counteracting the energy depletion and oxidative stress …

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DDTC-Cu(I) inhibits human osteosarcoma cells growth by repressing MET/PI3K/AKT signaling pathway

Ruhao Zhou, Lei Yan, Kun Zhang, Song Chen et autres

Osteosarcoma (OS) is a frequently occurring bone malignancy with increased metastatic properties, causing deaths in large numbers around the world. Disulfiram (DSF) is clinically utilized to treat alcohol dependency and has been indicated to bind Cu(I) in-vivo to form DDTC-Cu(I), which has …

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Risk Factors for Postoperative Neurologic Dysfunction in Patients with Spinal Tuberculosis: A Retrospective Study

Pengfei Shao, Yushan Wang, Mingjie Dong, Hao Fan et autres

Purpose: Unexplained neurological dysfunction often occurs in patients after spinal tuberculosis(STB) surgery; therefore, this study aimed to analyze the causes of this dysfunction from the perspectives of the patient's preoperative inflammatory state, carrier bacterial state, and increased degree of autoimmunity. Patients and …

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Donation After Circulatory Death in Heart Transplantation

Xiaoxue Zhang, Huan Wang, Yujie Yang, Xiantao Ma et autres

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Open ascending aorta replacement combined with fenestrated total aortic arch stenting

Xiantao Ma, Yi Feng, Chenhe Li, Ningxin Hou et autres

Objective: The aim of this retrospective single-center study was to report a novel hybrid technique of replacement of the ascending aorta and implantation of fenestrated stent-graft of the entire aortic arch for Stanford type A aortic dissection and to analyze clinical experience …

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Single-cell transcriptional profiling in osteosarcoma and the effect of neoadjuvant chemotherapy on the tumor microenvironment

Xiaoyu He, Liu-yi Que, Fan Yang, Yi Feng et autres

Osteosarcoma (OS), a malignant tumor, originates from the bone marrow. Currently, treatment for OS remains limited, making it urgent to understand the immune response in the tumor microenvironment of patients with OS. A comprehensive bioinformatics analysis was performed, including cell clustering subgroups, …

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Cisplatin and doxorubicin chemotherapy alters gut microbiota in a murine osteosarcoma model

Zhi Tian, Xiaochen Qiao, Zhichao Wang, Xiaoyan Li et autres

in the osteosarcoma animal model group returned to normal after CDDP or DOX treatment. Furthermore, the function of the gut microbiota was inferred through PICRUSt2 (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States), which indicated that metabolism-related microbiota was highly enriched …

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