2026
article
OpenAlex
Masao Nakajima, Yukio Tokumitsu, Yoshitaro Shindo, Hiroto Matsui et autres
Hepatocellular carcinoma (HCC) has a high recurrence rate even after curative resection or local ablation, and early recurrence within 1-2 years is often driven by intrahepatic metastasis and strongly affects prognosis. Immune checkpoint inhibitor (ICI)-based combination therapy has become a standard approach …
jp
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Accès ouvert
2026
article
OpenAlex
Michihisa Iida, Chiyo Nakashima, Toru Kawaoka, Junya Kondo et autres
Abstract Background Weekly paclitaxel combined with ramucirumab is the standard second-line chemotherapy regimen for advanced gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is increasingly used as it lowers the risk of hypersensitivity reactions; however, full-dose nab-paclitaxel (100 mg/m²) combined with ramucirumab frequently leads …
jp
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2026
article
OpenAlex
Tanios S. Bekaii-Saab, Davide Melisi, Hanneke Wilmink, Carlo Garufi et autres
PURPOSE Cholangiocarcinoma is a rare cancer associated with poor prognosis. Pemigatinib was the first FGFR1-3 inhibitor approved for second-line therapy and beyond, on the basis of the phase II FIGHT-202 trial. Here, we assess efficacy and safety of first-line pemigatinib. METHODS FIGHT-302 …
us, it, nl, se, es, gb, ca, jp, de
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2026
article
OpenAlex
松井 洋人, Takeshi Terashima, Takashi Mizuno, Yoshiharu Masaki et autres
TPS4252 Background: Gemcitabine plus cisplatin (GC) has been established as the standard first-line treatment for unresectable biliary tract cancer (BTC). Recent phase III trials have demonstrated the clinical benefit of adding immune checkpoint inhibitors (ICIs) to GC. Meanwhile, GC combined with S-1 …
jp
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2026
article
OpenAlex
Mari Nabeya, MASAO NAKAJIMA, Ryouichi Tsunedomi, Takahiro Ozasa et autres
Background/Aim: Tertiary lymphoid structures (TLSs) have prognostic relevance in various cancers; however, the relationship is complex and depends on TLS properties. In this study, we evaluated the prognostic significance of TLS spatial distribution and maturation in patients with pancreatic ductal adenocarcinoma (PDAC) …
jp
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Accès ouvert
2026
article
OpenAlex
Yusuke Sano, Riku Kajikawa, Junki Mizusawa, Tatsuya Ioka et autres
BACKGROUND: Two main therapeutic approaches are currently used for locally advanced pancreatic cancer (LAPC): chemoradiotherapy and systemic chemotherapy. It remains unclear which approach may be more promising, or whether these strategies should be considered alternative or complementary therapeutic options in the management …
jp
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Accès ouvert
2026
article
OpenAlex
Yusuke Sano, Riku Kajikawa, Junki Mizusawa, Tatsuya Ioka et autres
Supplementary Material 1.
jp
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Accès ouvert
2026
article
OpenAlex
Yusuke Sano, Riku Kajikawa, Junki Mizusawa, Tatsuya Ioka et autres
Supplementary Material 1.
jp
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Accès ouvert
2026
other
OpenAlex
Yusuke Sano, Riku Kajikawa, Junki Mizusawa, Tatsuya Ioka et autres
Abstract Background Two main therapeutic approaches are currently used for locally advanced pancreatic cancer (LAPC): chemoradiotherapy and systemic chemotherapy. It remains unclear which approach may be more promising, or whether these strategies should be considered alternative or complementary therapeutic options in the …
jp
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Yusuke Sano, Riku Kajikawa, Junki Mizusawa, Tatsuya Ioka et autres
Abstract Background Two main therapeutic approaches are currently used for locally advanced pancreatic cancer (LAPC): chemoradiotherapy and systemic chemotherapy. It remains unclear which approach may be more promising, or whether these strategies should be considered alternative or complementary therapeutic options in the …
jp
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2026
article
OpenAlex
Akira Ishii, Shinobu Tomochika, Yasuhiro Fujiwara, Hironori Tanaka et autres
A 74‒year‒old male was diagnosed with advanced rectal cancer with bowel obstruction, and abscess formation. After sigmoid colostomy, FOLFOXIRI plus bevacizumab as preoperative chemotherapy was initiated. On day 3, during continuous administration of 5‒fluorouracil(5‒FU), the patient developed impaired consciousness accompanied by convulsive …
jp
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Accès ouvert
2026
article
OpenAlex
Kou Kanesada, Masao Nakajima, Tatsuya Ioka, Shinobu Tomochika et autres
Background: Preoperative chemotherapy is increasingly used for colorectal liver metastases (CRLM), but simple risk stratification tools for routine practice remain limited. We developed a simple risk model to predict outcomes after curative-intent CRLM resection, including in patients receiving preoperative chemotherapy. Methods: We …
jp
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