Sergio Domenico Gadau

In vitro culture of cumulus–oocyte complexes from early antral follicles in prepubertal and adult ewes

Mohammadreza Ebrahimi, Laura Mara, Sara Succu, Sergio Domenico Gadau et autres

Abstract: The long-term in vitro culture (LIVC) of cumulus-oocyte complexes (COCs) derived from early antral follicles (EAFs) has shown significant potential in producing meiotically competent oocytes in adult ewes. However, the effectiveness of this approach in prepubertal ewes remains unexplored. This study …

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The effect of single versus group culture on cumulus-oocyte complexes from early antral follicles

Mohammadreza Ebrahimi, Laura Mara, Sara Succu, Sergio Domenico Gadau et autres

PURPOSE: This study aimed to evaluate the effectiveness of single versus group culture strategies for cumulus-oocyte complexes (COCs) derived from early antral follicles (EAFs), with the goal of optimizing culture conditions to increase oocyte availability for assisted reproductive technologies. METHODS: IU/mL FSH, …

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Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates

Gianluca Lepore, Sara Succu, Maria Grazia Cappai, Adele Frau et autres

Brain aging in mammals is characterized by morphological and functional changes in neural cells. Macroscopically, this process, leading to progressive cerebral volume loss and functional decline, includes memory and motor neuron deficits, as well as behavioral disorders. Morphologically, brain aging is associated …

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Does a relation between bone histomorphometry and fractures exist? The case of the equine radius and tibia

Marco Zedda, Ramona Babosová, Sergio Domenico Gadau, Gianluca Lepore et autres

Fractures of long bones in limbs are rare traumatic events in horses. This study investigates whether the incidence and types of fractures can be related to the histomorphometric features of the radius and tibia, which experience different biomechanical stresses and exhibit varying …

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Morphological and Metabolic Features of Brain Aging in Mammals

Gianluca Lepore, Sara Succu, Maria Grazia Cappai, Adele Frau et autres

Brain aging in mammals is characterized by morphological and functional changes of neural cells. Macroscopically, this process leading to progressive cerebral volume loss and functional decline, includes memory and motor neuron defiance and behavioral disorders as well. Morphologically, brain aging is associated …

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Identification of 3-Aryl-1-benzotriazole-1-yl-acrylonitrile as a Microtubule-Targeting Agent (MTA) in Solid Tumors

Stefano Zoroddu, Luca Sanna, Valentina Bordoni, Weidong Lyu et autres

Recently, a compound derived from recent scientific advances named 34 has emerged as the focus of this research, the aim of which is to explore its potential impact on solid tumor cell lines. Using a combination of bioinformatics and biological assays, this …

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In vitro culture of sheep early-antral follicles: Milestones, challenges and future perspectives

Mohammadreza Ebrahimi, Maria Dattena, Alberto Maria Luciano, Sara Succu et autres

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Fetal Growth and Osteogenesis Dynamics during Early Development in the Ovine Species

Sara Succu, Efisiangelo Contu, Daniela Bebbere, Sergio Domenico Gadau et autres

Increased knowledge of the developmental processes during gestation could provide valuable information on potential alterations in embryonic/fetal development. We examined the development of ovine conceptus between the 20th and 70th day of gestation with three convergent analyses: (1) uterus ultrasound examination and …

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Microtubular Assessment of C6 Rat Glioma Cell Spheroids Developed in Transparent Liquid Marbles or Hanging Drops

Arianna Langella, Sergio Domenico Gadau, Elisa Serra, Daniela Bebbere et autres

Glioblastoma is a brain tumour frequently used as an experimental model to exploit innovative therapeutic approaches due to its high lethality and refractoriness to therapies. Part of these innovative anticancer therapies address cytoskeletal microtubules (MTs) since specific tubulin post-translational modifications (PTMs) are …

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Vitrification of In Vitro Matured Oocytes Collected from Adult and Prepubertal Ovaries in Sheep

Sara Succu, Elisa Serra, Sergio Domenico Gadau, Antonio Varcasia et autres

In livestock, in vitro embryo production systems can be developed and sustained thanks to the large number of ovaries and oocytes that can be easily obtained from a slaughterhouse. Adult ovaries always bear several antral follicles, while in pre-pubertal donors the maximal …

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Vitrification of In Vitro Matured Oocytes Collected from Adult and Prepubertal Ovaries in Sheep

Sara Succu, Elisa Serra, Sergio Domenico Gadau, Antonio Varcasia et autres

In livestock, in vitro embryo production systems can be developed and sustained thanks to the large number of ovaries and oocytes that can be easily obtained from a slaughterhouse. Adult ovaries always bear several antral follicles, while in pre-pubertal donors the maximal …

it (code pays fourni par la source)

Seasonal Effect on Developmental Competence, Oxidative Status and Tubulin Assessment of Prepubertal Ovine Oocyte

Elisa Serra, Sergio Domenico Gadau, Giovanni Giuseppe Leoni, Salvatore Naitana et autres

The reproductive seasonality of domestic animals is often manipulated in order to have more reproductive periods for commercial purposes related to the production of milk and meat. It is scientifically proven that such an alteration of the reproductive activity in sheep entails …

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