Michael A. Crowe

Filling critical data gaps in High-Altitude Environments of the Himalayan Region

Dhiraj Pradhananga, Michael A. Crowe, Luna Bharati, Kumar Aryal et autres

This paper addresses the critical need for high-altitude weather, climate, and environment monitoring in the Himalayas, where the impacts of climate change, such as water and food insecurity, biodiversity loss, and increased extreme events, are increasingly felt. Despite the region’s vulnerability, existing …

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Abstract 2282: Rapid and accurate variant calling of FFPE samples with the genexus system

Iris Casuga, Jason Gioia, Janice Au-Young, Frances Chan et autres

Abstract Next Generation Sequencing technology has enhanced oncology research by enabling the detection of relevant variants for clinical and drug discovery programs. The Oncomine Comprehensive Assay v3, a pan-cancer panel, used with the Ion Torrent Genexus System allows for formalin-fixed paraffin embedded …

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Analytical method development for directed enzyme evolution research: A high throughput high-performance liquid chromatography method for analysis of ribose and ribitol and a capillary electrophoresis method for the separation of ribose enantiomers

Baoguo Sun, Gregory H. Miller, Wan Yee Lee, Kelvin Ho et autres

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CCDC 641481: Experimental Crystal Structure Determination

Carole Anastasi, Fabien F. Buchet, Michael A. Crowe, M. Helliwell et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 641482: Experimental Crystal Structure Determination

Carole Anastasi, Fabien F. Buchet, Michael A. Crowe, Madeleine Helliwell et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 636363: Experimental Crystal Structure Determination

M.W. Powner, Carole Anastasi, Michael A. Crowe, Alastair L. Parkes et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

RNA: Prebiotic Product, or Biotic Invention

Carole Anastasi, Fabien F. Buchet, Michael A. Crowe, Alastair L. Parkes et autres

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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On the Prebiotic Synthesis of Ribonucleotides: Photoanomerisation of Cytosine Nucleosides and Nucleotides Revisited

Matthew W. Powner, Carole Anastasi, Michael A. Crowe, Alastair L. Parkes et autres

Recent work has emphasised the importance of D-ribose aminooxazoline 1 in the synthesis of cytidine ribonucleosides under potentially prebiotic conditions. Upon treatment with cyanoacetylene, 1 is transformed into alpha-D-cytidine (alpha-2), and if an efficient means of anomerising this nucleoside or a derivative …

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RNA: Prebiotic Product, or Biotic Invention?

Carole Anastasi, Fabien F. Buchet, Michael A. Crowe, Alastair L. Parkes et autres

Spectacular advances in structural and molecular biology have added support to the 'RNA world' hypothesis, and provide a mandate for chemistry to explain how RNA might have been generated prebiotically on the early earth. Difficulties in achieving a prebiotically plausible synthesis of …

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Two-Step Potentially Prebiotic Synthesis of α- d -Cytidine-5‘-phosphate from d -Glyceraldehyde-3-phosphate

Carole Anastasi, Michael A. Crowe, John D. Sutherland

5‘-Ribonucleotide precursors of RNA have previously been difficult to synthesize under prebiotically plausible conditions because of the inaccessibility of ribose-5-phosphate. Here we demonstrate a process in which ribose-5-phosphate is bypassed, and a cytidine 5‘-ribonucleotide is efficiently assembled under mild conditions in two …

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Direct Assembly of Nucleoside Precursors from Two‐ and Three‐Carbon Units

Carole Anastasi, Michael A. Crowe, Matthew W. Powner, John D. Sutherland

Sweetness and life: Pentose aminooxazolines—intermediates in potentially prebiotic nucleoside synthesis—can be produced in water from a reaction that bypasses the corresponding sugar. 2-Aminooxazole, a condensation product of glycolaldehyde and cyanamide, reacts with glyceraldehyde under mild conditions in a remarkable process that is …

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Direct Assembly of Nucleoside Precursors from Two‐ and Three‐Carbon Units

Carole Anastasi, Michael A. Crowe, Matthew W. Powner, John D. Sutherland

Süßes Leben: Pentose-Aminooxazoline – Intermediate in einer möglichen präbiotischen Nucleosidsynthese – können in Wasser unter Umgehung des entsprechenden Zuckers hergestellt werden. 2-Aminooxazol, ein Kondensationsprodukt aus Glycolaldehyd und Cyanamid, reagiert mit Glyceraldehyd unter milden Bedingungen in einem bemerkenswerten und nahezu quantitativen Prozess, der …

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