Dietmar Marder

A Systematic Performance Evaluation of Three Large Language Models in Answering Questions on moderate Hyperthermia

Fabio Dennstädt, Nikola Čihorić, Nicolas Bachmann, I. Filchenko et autres

ABSTRACT Background Large Language Models (LLMs) have demonstrated expert-level performance across many medical domains, suggesting potential utility in clinical practice. However, their reliability in the highly specialized domain of moderate hyperthermia (HT) remains unknown. We therefore evaluated the performance of three modern …

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Toward enhanced quality assurance guidelines for deep hyperthermia devices: a multi-institution study

Mattia De Lazzari, Carolina Carrapiço-Seabra, Dietmar Marder, Gerard C. van Rhoon et autres

INTRODUCTION: Hyperthermia efficacy depends on the temperatures achieved in the target area. Therefore, hyperthermia systems must deliver both controlled and conformal heating. This study presents a comprehensive multi-institutional quality assurance (QA) evaluation of deep hyperthermia devices. METHODS: Six European institutions equipped with …

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Neoadjuvant chemoradiotherapy in combination with deep regional hyperthermia followed by surgery for rectal cancer: a systematic review and meta-analysis

Adela Ademaj, Sonja M. Stieb, Cihan Gani, Oliver J. Ott et autres

BACKGROUND AND PURPOSE: Combining chemoradiotherapy (CRT) with deep regional hyperthermia (HT) shows promise for enhancing clinical outcomes in selected rectal cancer patients. This study aimed to integrate the evidence and evaluate the efficacy of this combined treatment approach. MATERIALS AND METHODS: A …

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2890: Neoadjuvant chemoradiotherapy and hyperthermia for locally advanced rectal cancer

Adela Ademaj, Oliver J. Ott, Cihani Gani, Olav Mella et autres

1254: Tumor Control Probability predictions for Hyperthermia plus Radiotherapy under varying conditions

Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer et autres

Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia-Radiotherapy (HT-RT) treatments in-silico

Sergio Mingo Barba, Adela Ademaj, Dietmar Marder, Oliver Riesterer et autres

INTRODUCTION: biophysical models that translate deviations in the treatment conditions into clinical outcome variations may be used to study the extent of such processes and their influence on combined hyperthermia plus radiotherapy (HT + RT) treatments under varying conditions. METHODS: An extended …

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Radiotherapy combined with deep regional hyperthermia in elderly and frail patients with muscle-invasive bladder cancer: quality analysis of hyperthermia and impact on clinical results

Adela Ademaj, Emsad Puric, Dietmar Marder, Olaf Timm et autres

Purpose: Radiotherapy (RT) in combination with deep regional hyperthermia (HT) after transurethral removal of bladder tumor (TURBT) can be offered to elderly and frail patients with muscle-invasive bladder cancer (MIBC).Methods: In total, 21 patients (mean age 84 years) with unifocal or multifocal …

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Real World Analysis of Quality of Life and Toxicity in Cancer Patients Treated with Hyperthermia Combined with Radio(chemo)therapy

Adela Ademaj, Emsad Puric, Olaf Timm, David Kurti et autres

Hyperthermia (HT) in combination with radio(chemo)therapy (RCT) is a well-established cancer treatment strategy. This report analyses the quality of life (QoL), toxicity and survival outcomes in patients with different tumor entities who received HT in combination with RCT. The primary endpoint of …

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A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Adela Ademaj, Paraskevi Danai Veltsista, Dietmar Marder, Roger A. Hälg et autres

PURPOSE: The combination of hyperthermia (HT) with radio(chemo)therapy or chemotherapy (CT) is an established treatment strategy for specific indications. Its application in routine clinical practice in Europe depends on regulatory and local conditions. We conducted a survey among European clinical centers to …

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Tetramodal therapy with transurethral resection followed by chemoradiation in combination with hyperthermia for muscle-invasive bladder cancer: early results of a multicenter phase IIB study

Oliver Riesterer, Adela Ademaj, Emsad Puric, Brigitte Eberle et autres

BACKGROUND: Transurethral resection of bladder tumor (TUR-BT) followed by chemoradiation (CRT) is a valid treatment option for patients with muscle-invasive bladder cancer (MIBC). This study aimed to investigate the efficacy of a tetramodal approach with additional regional hyperthermia (RHT). METHODS: Patients with …

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Present Practice of Radiative Deep Hyperthermia in Combination with Radiotherapy in Switzerland

Emanuel Stutz, Emsad Puric, Adela Ademaj, Arnaud Künzi et autres

BACKGROUND: Moderate hyperthermia is a potent and evidence-based radiosensitizer. Several indications are reimbursed for the combination of deep hyperthermia with radiotherapy (dHT+RT). We evaluated the current practice of dHT+RT in Switzerland. METHODS: All indications presented to the national hyperthermia tumor board for …

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Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Adela Ademaj, Danai P. Veltsista, Pirus Ghadjar, Dietmar Marder et autres

Hyperthermia (HT) is a cancer treatment modality which targets malignant tissues by heating to 40-43 °C. In addition to its direct antitumor effects, HT potently sensitizes the tumor to radiotherapy (RT) and chemotherapy (CT), thereby enabling complete eradication of some tumor entities …

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