Accès ouvert
2021
article
OpenAlex
Christine Baksmeier, Patricia A. Blundell, Julia Steckel, Verena Schultz et autres
Intravenous immunoglobulin (IVIG) is an established treatment for numerous autoimmune conditions. Although Fc fragments derived from IVIG have shown efficacy in controlling immune thrombocytopenia in children, the mechanisms of action are unclear and controversial. The aim of this study was to dissect …
de, gb, cn
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Accès ouvert
2020
article
OpenAlex
Michael Dietrich, Valeria Koska, Christina Hecker, Peter Göttle et autres
Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action is via blockade of axonal voltage gated potassium channels, thereby …
de, nl, es, ch, us
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Accès ouvert
2017
article
OpenAlex
Manish Malviya, Sumanta Barman, Kristin S. Golombeck, Jesús Planagumà et autres
Objective: Autoimmune encephalitis is most frequently associated with anti-NMDAR autoantibodies. Their pathogenic relevance has been suggested by passive transfer of patients' cerebrospinal fluid (CSF) in mice in vivo. We aimed to analyze the intrathecal plasma cell repertoire, identify autoantibody-producing clones, and characterize …
de, es, us
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Meike Winter, Christine Baksmeier, Julia Steckel, Sumanta Barman et autres
OBJECTIVE: model of the central nervous system (CNS)-immune interface. METHODS: Using organotypic cerebellar slice cultures (OSC) from transgenic mice expressing green fluorescent protein (GFP) in oligodendrocytes/myelin, we induced extensive immune-mediated demyelination and oligodendrocyte loss with an antibody specific for myelin oligodendrocyte glycoprotein …
de, sk
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