Carlo Maria Bellanca

Smoking cessation and harm reduction in type 2 diabetes: development of practical recommendations from the DiaSmokeFree Working Group

Magdalena Walicka, Giusy Rita Maria La Rosa, Antonio Ceriello, Alison Martin et autres

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Latest developments in the use of e-cigarettes by people with schizophrenia spectrum disorders who smoke: a scoping review

Pasquale Caponnetto, Sarah Pratt, Carlo Maria Bellanca, Noemi Maria Vitale et autres

Background: Tobacco use is significantly more prevalent among individuals with schizophrenia spectrum disorders (SSD) compared to the general population, contributing to elevated rates of premature mortality from smoking-related diseases. Despite a decline in smoking prevalence in the general population, individuals with SSD …

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Infectious Complications in Metabolic and Bariatric Surgery: A Comprehensive Narrative Review of Pathophysiology, Prevention, and Management

Marcello Agosta, Egle Augello, Carlo Maria Bellanca, Andrea Marino et autres

BACKGROUND: Metabolic and bariatric surgery is an established therapeutic option for severe obesity and obesity-related medical problems. Although minimally invasive techniques and enhanced recovery pathways have reduced postoperative morbidity, infectious complications remain clinically relevant because they may lead to readmission, reoperation, prolonged …

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From pharmacokinetic genes to polygenic scores and multi-omic integration: advances toward precision psychiatry

Carlo Maria Bellanca, Alessio Squassina, Mirko Manchia, Pasquale Paribello et autres

INTRODUCTION: Pharmacological treatment is the mainstay in the acute and long-term management of severe mental disorders such as major depressive disorder, schizophrenia, and bipolar disorder. However, there is large interindividual variability in clinical response, with around one-third of patients presenting treatment-resistance. AREAS …

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Addressing the dual challenge: Managing smoking cessation in patients with diabetes

Cristina Russo, Magdalena Walicka, Gal Cohen, Carlo Maria Bellanca et autres

Smoking increases complications and mortality in people with diabetes. Quitting delivers major benefits, but physiological (weight gain, insulin sensitivity shifts) and psychological barriers make cessation harder in this group. Our review article examined strategies tailored to people with diabetes. All smokers with …

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Antibiotic Therapy Duration for Multidrug-Resistant Gram-Negative Bacterial Infections: An Evidence-Based Review

Andrea Filippo Marino, Egle Augello, Carlo Maria Bellanca, Federica Cosentino et autres

Determining the optimal duration of antibiotic therapy for infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB) is a critical challenge in clinical medicine, balancing therapeutic efficacy against the risks of adverse effects and antimicrobial resistance. This narrative review synthesises current evidence and guidelines …

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A scoping review about smoking, smoking cessation and their effects on anti-tuberculosis agents: insights into drug metabolisms, safety, and effectiveness

Carlo Maria Bellanca, Simone Pietro Polosa, Egle Augello, Giulia Di Benedetto et autres

The World Health Organization (WHO) ranks tuberculosis (TB) as one of the top 10 causes of deaths worldwide. Notably, tobacco smoking represents a significant promoting factor in TB progression, being associated with poorer treatment outcomes, delayed conversion to negative smear or culture, …

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Targeted delivery of sorafenib via biotin decorated polyaminoaspartamide-based nanoparticles for the hepatocarcinoma treatment

Giulia Di Benedetto, Paola Varvarà, Salvatore Emanuele Drago, Anna Flavia Cantone et autres

Hepatocellular carcinoma (HCC), the most common primary liver cancer, faces treatment challenges due to drug resistance and poor bioavailability, with sorafenib, a key therapy, characterized by rapid clearance and significant side effects. This paper describes the development of amphiphilic graft copolymers for …

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Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer’s Disease

Anna Flavia Cantone, Chiara Burgaletto, Giulia Di Benedetto, Gabriella Gaudio et autres

Abstract Alzheimer’s disease (AD) is the most common cause of dementia worldwide, characterized by accumulation of amyloid-β protein and hyperphosphorylated tau protein in the brain. Neuroinflammation, resulting from chronic activation of brain-resident innate immune cells as well as enhanced peripheral leukocyte access …

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Personalized and adaptive interventions for smoking cessation: Emerging trends and determinants of efficacy

Gal Cohen, Carlo Maria Bellanca, Renato Bernardini, Jed E. Rose et autres

Cigarette smoking addiction is a leading cause of morbidity and mortality and presents a challenging interventional target. Interventions for stopping smoking offer trade-offs in ability to displace or blunt the effects of cigarettes, which include positive and negative reinforcement, psychological reward, aversiveness, …

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Unveiling the Secrets of Acinetobacter baumannii: Resistance, Current Treatments, and Future Innovations

Andrea Filippo Marino, Egle Augello, Stefano Stracquadanio, Carlo Maria Bellanca et autres

Acinetobacter baumannii represents a significant concern in nosocomial settings, particularly in critically ill patients who are forced to remain in hospital for extended periods. The challenge of managing and preventing this organism is further compounded by its increasing ability to develop resistance …

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A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

Carlo Maria Bellanca, Egle Augello, Giulia Di Benedetto, Chiara Burgaletto et autres

Currently 1.3 billion individuals globally engage in smoking, leading to significant morbidity and mortality, particularly among diabetic patients. There is urgent need for a better understanding of how smoking influences antidiabetic treatment efficacy. The review underscores the role of cigarette smoke, particularly …

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