Paulo Durão

Citizen Science to Raise Antimicrobial Resistance Awareness in the Community: The MicroMundo Project in Spain and Portugal

Jéssica Gil-Serna, Patrı́cia Antunes, Susana Campoy, Ángeles Cid et autres

Antimicrobial resistance (AMR) poses a global threat to human, animal and environmental health. Among the multidisciplinary tasks aimed at collectively tackling the AMR crisis, surveillance, research and education stand as major priorities. Based on a crowdsourcing research strategy, the MicroMundo project, a …

es, pt (code pays fourni par la source)

Optimized protocols to measure stability of ligninolytic enzymes

Vânia Brissos, Paulo Durão, Carolina F. Rodrigues, Eduardo P. Melo et autres

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MicroMundo@Oeiras: citizen science promoting antibiotic stewardship, discovery of new antimicrobials, and monitoring of soil resistance

Benito Guimarães de Brito, Catarina Barreiros, Guilherme Galvão, João Coito et autres

The alarming rise of antimicrobial resistance (AMR) is an emerging public health challenge to our society. Although resistance is an inevitable evolutionary process, finding new antimicrobials, mapping AMR, and raising community awareness leading to better hygiene attitudes and more responsible antibiotic consumption, …

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Respiratory viral infections before the COVID-19 in Portugal: A single center study

Vera Durão, Vera Clérigo, Paulo Durão, Ana Catarina da Silva Alfaiate et autres

Objectives: We aimed to describe the respiratory viruses (RV) found in respiratory samples from patients admitted to Hospital de São Bernardo, Setúbal, Portugal, between October 2019 and March 2020, and to correlate these with clinical features. Design: This retrospective study explored 948 …

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Environmentally Friendly Degradation and Detoxification of Rifampicin by a Bacterial Laccase and Hydrogen Peroxide

Paulo Durão, Peter Kis, Ivo M. Chelo, Maria Rita Ventura et autres

Antibiotics are micropollutants accumulating in our rivers and wastewaters, potentially leading to bacterial antibiotic resistance, a worldwide problem to which there is no current solution. Here, we have developed an environmentally friendly two-step process to transform the antibiotic rifampicin (RIF) into non-antimicrobial …

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Competition dynamics in long‐term propagations of Schizosaccharomyces pombe strain communities

Paulo Durão, Massimo Amicone, Lília Perfeito, Isabel Gordo

Abstract Experimental evolution studies with microorganisms such as bacteria and yeast have been an increasingly important and powerful tool to draw long‐term inferences of how microbes interact. However, while several strains of the same species often exist in natural environments, many ecology …

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Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut

Luís Leónidas Cardoso, Paulo Durão, Massimo Amicone, Isabel Gordo

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Radial Expansion Facilitates the Maintenance of Double Antibiotic Resistances

Paulo Durão, Ricardo S. Ramiro, Cátia Pereira, Jernej Jurič et autres

Most microbes live in spatially confined subpopulations. Under spatial structure conditions, the efficacy of natural selection is often reduced (relative to homogeneous conditions) due to the increased importance of genetic drift and local competition. Additionally, under spatial structure conditions, the fittest genotype …

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Low mutational load and high mutation rate variation in gut commensal bacteria

Ricardo S. Ramiro, Paulo Durão, Claudia Bank, Isabel Gordo

Bacteria generally live in species-rich communities, such as the gut microbiota. Yet little is known about bacterial evolution in natural ecosystems. Here, we followed the long-term evolution of commensal Escherichia coli in the mouse gut. We observe the emergence of mutation rate …

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Dysbiosis personalizes fitness effect of antibiotic resistance in the mammalian gut

Luís Leónidas Cardoso, Paulo Durão, Massimo Amicone, Isabel Gordo

SUMMARY The fitness cost of antibiotic resistance in the absence of antibiotics is crucial to the success of suspending antibiotics as a strategy to lower resistance. Here we show that after antibiotic treatment the cost of resistance within the complex ecosystem of …

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Low Mutational Load Allows for High Mutation Rate Variation in Gut Commensal Bacteria

Ricardo S. Ramiro, Paulo Durão, Claudia Bank, Isabel Gordo

Abstract Bacteria generally live in species-rich communities, such as the gut microbiota. Yet, little is known about bacterial evolution in natural ecosystems. Here, we followed the long-term evolution of commensal Escherichia coli in the mouse gut. We observe the emergence of polymorphism …

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Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines

Vera Durão, Anabela G. Silva, Rita Macedo, Paulo Durão et autres

SETTING: Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is, however, very little information on the prevalence of NTM drug resistance in Portugal. OBJECTIVE AND DESIGN: Our aim was …

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