Christian Holland

The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers

Sheila Lumley, Jia Wei, Denise O’Donnell, Nicole Stoesser et autres

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody measurements can be used to estimate the proportion of a population exposed or infected and may be informative about the risk of future infection. Previous estimates of the duration of …

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A nudge towards better lumbar puncture practice

Christian Holland, Evan Edmond, Catherine Moore, Vanessa Tobert et autres

BACKGROUND: Despite a body of evidence demonstrating reduced incidence of post-lumbar puncture headache associated with pencil-point (vs bevelled-edge) needles, their use remains variable in the UK. METHODS: A multimodal longitudinal intervention was performed over a 12-month period at a tertiary neurology referral …

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Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

David W. Eyre, Sheila Lumley, Denise O’Donnell, Mark Campbell et autres

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, …

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Author response: Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

David W. Eyre, Sheila Lumley, Denise O’Donnell, Mark Campbell et autres

Risk factors for SARS-CoV-2 infection in healthcare workers included caring for Covid-19 patients, Black or Asian ethnicity, and Covid-19-positive household contacts, whereas a bundle of PPE-related measures protected ICU staff.

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027 Promoting atraumatic needle usage for lumbar puncture in neurology: the power of the default

Christian Holland, Catherine Moore, Vanessa Tobert, James Allen et autres

Lumbar puncture (LP) is a key diagnostic investigation in neurology. Post-dural puncture headache (PDPH) is a known complication of lumbar puncture, resulting in significant patient morbidity. Fine-gauge and atraumatic-tip needles have been shown to reduce significantly the risk of PDPH. While uptake …

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Behandlungsfehlervorwürfe bei der Chirotherapie

Christian Holland, B. Weber

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Sleep homeostasis inDrosophila: a window on the vital function of sleep

Christian Holland

The function of sleep is one of the enduring mysteries of modern neuroscience.Despite years of concerted research, it is still unclear why all known animals undergo a regular period of unconsciousness and what function this fulfils that simply cannot be performed during …

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AR/VR/MR Immersive Media Infrastructure and Technology

Christian Holland, Maggie Franzen, Riley Mahr

The exponential rise of developing technologies has left the world with the ongoing question, "What is the next big medium?" This is what Professor Christopher Willey and I have been researching within the Immersive Media Lab, and the results have generated a …

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland et autres

Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic islets. In …

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Vermeintlich gesichertes Wissen

Christian Holland

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Episode 14: Christian Holland

Thomas Kenny, Christian Holland

In Reply

Christian Holland

Low-dose Analgesic Radiotherapy Is a Real AlternativeAs board members of the working group "Gutartige Erkrankungen [benign disorders]" within the German Society of Radiation Oncology (DEGRO, Deutsche Gesellschaft für Radioonkologie), we read the original article by Holland et al. with great interest.The article …