Roman Manuel Stilling

Kompass Tierversuche 2026 - Abbilden. Einordnen. Erklären.

Stefan Treue, Laura Berg, Jana Wilken, Roman Manuel Stilling et autres

Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

Lívia H. Morais, Anna V. Golubeva, Gerard M. Moloney, Ángela Moya-Pérez et autres

Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. Moreover, alterations of the microbiome have been shown to affect neurodevelopmental trajectories. However, the long-term effects of C-section on neurobehavioral …

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Host Microbiota Regulates Central Nervous System Serotonin Receptor 2C Editing in Rodents

Marcel van de Wouw, Roman Manuel Stilling, Veronica L. Peterson, Feargal J. Ryan et autres

Microbial colonization of the gastrointestinal tract plays a crucial role in the development of enteric and central nervous system functionality. The serotonergic system has been heavily implicated in microbiota–gut–brain axis signaling, particularly in proof-of-principle studies in germ-free (GF) animals. One aspect of …

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Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

Roman Manuel Stilling, Gerard M. Moloney, Feargal J. Ryan, Alan E. Hoban et autres

Social behaviour is regulated by activity of host-associated microbiota across multiple species. However, the molecular mechanisms mediating this relationship remain elusive. We therefore determined the dynamic, stimulus-dependent transcriptional regulation of germ-free (GF) and GF mice colonised post weaning (exGF) in the amygdala, …

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Author response: Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

Roman Manuel Stilling, Gerard M. Moloney, Feargal J. Ryan, Alan E. Hoban et autres

Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.

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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena‐Centeno et autres

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads …

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The orphan nuclear receptor TLX regulates hippocampal transcriptome changes induced by IL-1β

Ciarán S. Ó’Léime, Alan E. Hoban, Cara M. Hueston, Roman Manuel Stilling et autres

TLX is an orphan nuclear receptor highly expressed within neural progenitor cells (NPCs) in the hippocampus where is regulates proliferation. Inflammation has been shown to have negative effects on hippocampal function as well as on NPC proliferation. Specifically, the pro-inflammatory cytokine IL-1β …

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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity After Environmental Enrichment

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Qihui Zhou et autres

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RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Qihui Zhou et autres

ABSTRACT Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning & memory and lower the risk for various complex diseases including Alzheimer’s disease. Here we show that exposure of adult male mice to an environmental enrichment paradigm …

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Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

Alan E. Hoban, Roman Manuel Stilling, Gerard M. Moloney, Rachel D. Moloney et autres

BACKGROUND: There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using germ-free (GF) animals have been essential in contributing to our current understanding of the potential importance of …

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KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions

Cemil Kerimoglu, Mohammad Sadman Sakib, Gaurav Jain, Eva Benito et autres

Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation. We compare the decrease in H3K4 methylation and de-regulation …

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HDAC1 links early life stress to schizophrenia-like phenotypes

Sanaz Bahari‐Javan, Hristo Varbanov, Rashi Halder, Eva Benito et autres

Significance Early life stress (ELS) is an important risk factor for schizophrenia. Our study shows that ELS in mice increases the levels of histone-deacetylase (HDAC) 1 in brain and blood. Although altered Hdac1 expression in response to ELS is widespread, increased Hdac1 …

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