Zhenxing Fu

Selective cGAS Inhibition Is Cardioprotective After Myocardial Infarction

Van K. Ninh, Kelly A. Pike, Betul Beyza Gunes, Gilda Castellanos et autres

Activation of the DNA sensor cGAS has emerged as a potential driver of maladaptive inflammation after myocardial infarction. In this study, the authors provide evidence that a newly developed pharmacologic cGAS inhibitor improves cardiac recovery following myocardial infarction. The compound, which can …

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BNP is Selectively Produced by Amyloid-Associated Cardiomyocytes at Amyloid Border Zones in Patients with Cardiac Amyloidosis

B O Zhang, Van Ninh, Gilda Gastianos, J. Yu et autres

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Stress competition mechanism and ultra-clean process optimization of Marangoni drying for weak-hydrophilic 4H-SiC wafers

M Li, Huiqing Chen, Dapeng Chang, Dongyue Wu et autres

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Composite-subspace neural solvers with explicit boundary-layer bases for singularly perturbed problems

Zhenxing Fu, hongliang liu, Zhiqiang Sheng

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael Nguyen et autres

To mitigate the pathological effects of myocardial infarction, we developed and investigated a pro-reparative decellularized extracellular matrix (ECM) biomaterial, an intravascularly infusible ECM (iECM). However, the cellular and molecular mechanisms by which iECM mediates repair are unknown because investigations have relied on …

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Regional and cell specific bioactivity of injectable extracellular matrix biomaterials in myocardial infarction

Joshua M. Mesfin, Van K. Ninh, Miranda D. Diaz, Michael Nguyen et autres

Myocardial infarction (MI) remains a global health concern. To mitigate subacute and chronic MI pathophysiology, we previously investigated a pro-reparative decellularized extracellular matrix hydrogel. Despite increasing interest in biomaterial scaffolds, single cell and spatially resolved transcriptomics have not been used to probe …

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Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction

Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael Nguyen et autres

To mitigate the pathological effects of myocardial infarction, we developed and investigated pro-reparative decellularized extracellular matrix (ECM) biomaterials: an intravascularly infusible ECM (iECM). However, the cellular and molecular mechanisms by which iECM mediates repair are unknown because investigations have relied on bulk …

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Research progress in RBC alloimmunization

Zhenxing Fu, Hao Xinxin, Wei Gao, Q Wang

Red blood cell (RBC) alloimmunization is a common and clinically significant immunological phenomenon in transfusion medicine, pregnancy management, and organ transplantation. It involves complex interactions between RBC antigens and the host immune system. Recent studies have revealed that RBCs are not merely …

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Aggregation-induced-emission based Y-assembly artificial light-harvesting system: Design and application of white-light-emitting gel materials

Juan Zhang, Tingting Zhang, Yanyan Li, Yuehua Liang et autres

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Growth of low resistivity p-type 4H-SiC single crystals by physical vapor transport using a novel crucible structure

Wenhao Han, Guanglei Zhong, Xuejian Xie, Xiufang Chen et autres

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Uncovering the Regional and Cell Specific Bioactivity of Injectable Extracellular Matrix Biomaterials in Myocardial Infarction through Spatial and Single Nucleus Transcriptomics

Joshua M. Mesfin, Van K. Ninh, Miranda D. Diaz, Michael Nguyen et autres

Myocardial infarction (MI) remains a global health concern. To mitigate MI pathophysiology, we previously investigated a pro-reparative decellularized extracellular matrix (ECM) hydrogel for treating subacute and chronic MI. Despite increasing interest in biomaterial scaffolds, single cell and spatially resolved transcriptomics have not …

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Study on the Mechanism of Facet Formation Based on the Shape of Temperature Field

Hua Shao, Xixi Xiong, Xianglong Yang, Desheng Wang et autres

This paper presents a systematic study of the facet formation on the wafer surface at the end of large-diameter 4H-SiC crystal growth, guided by numerical simulations. The influence of different temperature field shapes on facet position and shape was examined through resistivity …

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