Jonah A. Padawer-Curry

131. Hemodynamic and Neural Effects of Psychedelics on Mice and Men

Jonah A. Padawer-Curry, Oliver J. Krentzman, Chao‐Cheng Kuo, Xiaodan Wang et autres

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Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function

Jonah A. Padawer-Curry, Oliver J. Krentzman, Chao‐Cheng Kuo, Xiaodan Wang et autres

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Multi-limbed optogenetic motor mapping in awake mice reveals cortical organization of coordinated movements

Nischal Khanal, Jonah A. Padawer-Curry, Trevor Voss, Kevin L. Schulte et autres

Evolution of spatiotemporal cortical dynamics in mice learning operant motor tasks

Evan W. Morris, Jonah A. Padawer-Curry, Zachary C. Lieske, Annie R. Bice et autres

We have developed a novel method to map cortical neuronal and hemodynamic activity in mice during operant motor tasks. Mice are trained over a 7-week period to execute a cued, center-out reaching task during concurrent wide-field optical imaging. Mice are able to …

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Infant mice receiving fractionated whole-brain radiation exhibit functional network disorganization as adults

Jiantao Zhu, Benjamin A. Seitzman, Francisco J. Reynoso, Timothy J. Mitchell et autres

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Region-specific non-rapid eye movement delta activity is associated with stroke recovery

Eric C. Landsness, Hanyang Miao, Wei Chen, Ryan M. Bowen et autres

Neural activity in the delta range (1.0-4.5 Hz) during non-rapid eye movement (NREM) sleep is crucial for brain plasticity and overall brain health. Recent research has shown that changes in NREM delta activity can occur locally, and activity can vary across different …

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Control of neurovascular coupling by ATP-sensitive potassium channels

Ryan M. Bowen, N York, Jonah A. Padawer-Curry, Adam Q. Bauer et autres

Regional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demonstrate the striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (K ATP ) channels in control of NVC …

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Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice

Ryan M. Bowen, Jake J. Lee, Bangjie Wang, Keith Robert Lohse et autres

Significance: Stroke is the leading cause of chronic disability in the United States. How stroke size affects post-stroke repair and recovery is poorly understood. Aim: We aim to investigate the effects of stroke size on early repair patterns and determine how early …

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Concurrent optogenetic motor mapping of multiple limbs in awake mice reveals cortical organization of coordinated movements

Nischal Khanal, Jonah A. Padawer-Curry, Trevor Voss, Annie R. Bice et autres

BACKGROUND: Motor mapping allows for determining the macroscopic organization of motor circuits and corresponding motor movement representations on the cortex. Techniques such as intracortical microstimulation (ICMS) are robust, but can be time consuming and invasive, making them non-ideal for cortex-wide mapping or …

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Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain

Jonah A. Padawer-Curry, Annie R. Bice, Byungchan Kim, Zachary Pollack Rosenthal et autres

Neurovascular coupling (NVC) and neurometabolic coupling (NMC) provide the basis for functional magnetic resonance imaging and positron emission tomography to map brain neurophysiology. While increases in neuronal activity are often accompanied by increases in blood oxygen delivery and oxidative metabolism, these observations …

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Psilocybin desynchronizes the human brain

Joshua S. Siegel, Subha Subramanian, Demetrius Perry, Benjamin P. Kay et autres

. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roughly 18 magnetic resonance imaging visits per participant). Healthy adults were tracked before, during …

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Concurrent optogenetic motor mapping of multiple limbs in awake mice reveals cortical organization of coordinated movements

Nischal Khanal, Jonah A. Padawer-Curry, Trevor Voss, Kevin L. Schulte et autres

Background: Motor mapping allows for determining the macroscopic organization of motor circuits and corresponding motor movement representations on the cortex. Techniques such as intracortical microstimulation (ICMS) are robust, but can be time consuming and invasive, making them non-ideal for cortex-wide mapping or …

us (code pays fourni par la source)