Nandan Deshpande

Molecular landscape of respiratory infection: A large-scale, multi-centre blood transcriptome dataset

Tracy Chew, Tiana Maria Pelaia, Amy L. Phu, Sally Teoh et autres

Respiratory infections pose significant challenges to global health, impacting millions of individuals annually. Understanding the molecular mechanisms underlying the pathogenicity of these infections is crucial for developing effective interventions. RNA sequencing provides insights into a patient's global transcriptome changes, facilitating the identification …

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The Stool and Oral Microbiome of Rheumatoid Arthritis Patients Taking Disease‐Modifying Antirheumatic Drugs

Lara Bereza-Malcolm, Tom Lynch, Nandan Deshpande, Andreas Orsmond et autres

Objective: Rheumatoid arthritis (RA) is a common musculoskeletal condition with an estimated prevalence of 0.27% in Australia and New Zealand. Recently, interest in the role of the human microbiome regarding RA pathogenesis has increased. This study is aimed at determining the composition …

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Deep Immune and RNA Profiling Revealed Distinct Circulating CD163+ Monocytes in Diabetes-Related Complications

Elisha Siwan, Jencia Wong, Belinda A. Brooks, Diana Shinko et autres

CD163, a scavenger receptor with anti-inflammatory function expressed exclusively on monocytes/macrophages, is dysregulated in cases of diabetes complications. This study aimed to characterize circulating CD163+ monocytes in the presence (D+Comps) or absence (D−Comps) of diabetes-related complications. RNA-sequencing and mass cytometry were conducted …

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Author Correction: Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial

Carolyn J. Hogg, Richard J. Edwards, Katherine A. Farquharson, Luke W. Silver et autres

In the version of the article initially published, in the “Bilby chromosomes” section, the sentence “The Ninu genome provides insights into chromosome evolution showing the Ninu XY 1 Y 2 system was generated by fusion of the X with a telocentric autosome” …

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Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial

Carolyn J. Hogg, Richard J. Edwards, Katherine A. Farquharson, Luke W. Silver et autres

Abstract Ninu (greater bilby, Macrotis lagotis ) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers and conservation managers, we generated the Ninu chromosome-level genome assembly (3.66 Gbp) and genome sequences for the extinct Yallara (lesser bilby, Macrotis leucura …

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Effect of probiotics and prebiotics on the composition of the equine fecal and seminal microbiomes and sperm quality: A pilot study

Carolyn Giselle Cooke, Zamira Gibb, Christopher G. Grupen, Kathrin Schemann et autres

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The semen microbiome of miniature pony stallions

Carolyn Giselle Cooke, Zamira Gibb, Christopher G. Grupen, Kathrin Schemann et autres

CONTEXT: Little is known about the microbial composition of stallion semen. AIMS: To describe the microbiota detected in equine semen of healthy miniature pony stallions. METHODS: Semen specimens were collected using a Missouri artificial vagina at a single time point. PacBio (Pacific …

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Effect of insulin insufficiency on ultrastructure and function in skeletal muscle

Chantal Kopecky, Michael Haug, Barbara Reischl, Nandan Deshpande et autres

Abstract Background Decreased insulin availability and high blood glucose levels, the hallmark features of poorly controlled diabetes, drive disease progression and are associated with decreased skeletal muscle mass. We have shown that mice with β‐cell dysfunction and normal insulin sensitivity have decreased …

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Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial

Carolyn J. Hogg, Richard J. Edwards, Katherine A. Farquharson, Luke W. Silver et autres

au, us, sg, es (code pays fourni par la source)

ApoA-I Protects Pancreatic β-Cells From Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin

Bikash Manandhar, Elvis Pandžić, Nandan Deshpande, Sing-Young Chen et autres

BACKGROUND: High cholesterol levels in pancreatic β-cells cause oxidative stress and decrease insulin secretion. β-cells can internalize apo (apolipoprotein) A-I, which increases insulin secretion. This study asks whether internalization of apoA-I improves β-cell insulin secretion by reducing oxidative stress. METHODS: Ins-1E cells …

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ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin

Bikash Manandhar, Elvis Pandžić, Nandan Deshpande, Sing-Young Chen et autres

ABSTRACT Objective: High cholesterol levels in pancreatic β-cells cause oxidative stress and decrease insulin secretion. β-cells can internalize apolipoprotein (apo) A-I, which increases insulin secretion. This study asks whether internalization of apoA-I improves β-cell insulin secretion by reducing oxidative stress. Approach: Ins-1E …

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Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia

Govardhan Anande, Nandan Deshpande, Sylvain Mareschal, Aarif M.N. Batcha et autres

Supplementary Figure 4, related to main Figure 5. Data pertaining to independent validation in the BEAT-AML cohort.