MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans
Yoonji Jung, Murat Artan, Nari Kim, Jeonghun Yeom et autres
. Consistently, we showed that mammalian MON2 activated GABARAPL2 through physical interaction, which increased autophagic flux in mammalian cells. Thus, the evolutionarily conserved role of MON2 in trafficking between the Golgi and endosome is an integral part of autophagy-mediated longevity.
kr, us (code pays fourni par la source)