Sofia Marques

Host cell traversal by Plasmodium parasites is essential for sterilizing hepatic cellular immunity

Ana Rodrigues, António M. Mendes, Rute Gonçalves, Helena Nunes‐Cabaço et autres

SUMMARY An effective vaccine capable of inducing sterile protection against Plasmodium , the causative agent of malaria, is critical to aid global eradication. Whole-organism vaccines using liver-infective sporozoites provide high levels of sterile protection against pre-erythrocytic infection. Yet, determinants of sporozoite immunogenicity …

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The resilience of vaccine serotypes in adult invasive pneumococcal disease in Portugal, 2018–2023

Andreia Guerreiro-Nunes, Catarina Silva‐Costa, Joana Gomes‐Silva, Mário Ramirez et autres

In Portugal, after a decline in the proportion of adult invasive pneumococcal disease (IPD) associated with serotypes included in PCV7 and PCV13 attributed to their use in children, we observed a stabilization in the number of IPD episodes caused by serotypes included …

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Correction to: Pneumococci remain the main cause of complicated pediatric pneumonia in the post-pandemic era despite extensive pneumococcal vaccine use

Joana Gomes‐Silva, Marcos D. Pinho, Ana Friães, Mário Ramirez et autres

pt, py (code pays fourni par la source)

CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection

Aparajita Lahree, Sofia Marques, Inês Bento, João Mello-Vieira et autres

The circumsporozoite protein (CSP), an essential protein that covers the surface of the Plasmodium sporozoite, is a key player in multiple stages of the parasite development within the mosquito and during interactions between sporozoites and mammalian hepatocytes. Here, we identify a novel …

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Pneumococci remain the main cause of complicated pediatric pneumonia in the post-pandemic era despite extensive pneumococcal vaccine use

Joana Gomes‐Silva, Marcos D. Pinho, Ana Friães, Mário Ramirez et autres

Nucleic acid amplification tests (NAATs) greatly enhance the capacity to identify the etiology of pediatric complicated pneumonia. However, the use of pneumococcal conjugate vaccines could reduce the importance of Streptococcus pneumoniae in pediatric complicated pneumonia with the potential emergence of other bacterial …

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A new role for erythropoietin in the homeostasis of red blood cells

Clemente Fernandez Arias, Nuno Valente-Leal, Federica Bertocchini, Sofia Marques et autres

The regulation of red blood cell (RBC) homeostasis is widely assumed to rely on the control of cell production by erythropoietin (EPO) and the destruction of cells at a fixed, species-specific age. In this work, we show that such a regulatory mechanism …

es, pt (code pays fourni par la source)

A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency

Inês M. Marreiros, Sofia Marques, Ana Parreira, Vincent Mastrodomenico et autres

Eukaryotes have canonical pathways for responding to amino acid (AA) availability. Under AA-limiting conditions, the TOR complex is repressed, whereas the sensor kinase GCN2 is activated. While these pathways have been highly conserved throughout evolution, malaria parasites are a rare exception. Despite …

pt, us, se (code pays fourni par la source)

Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis

Ângelo Ferreira Chora, Sofia Marques, Joana Lisboa Gonçalves, Priscila Bezerra De Lima et autres

Plasmodium replicates within the liver prior to reaching the bloodstream and infecting red blood cells. Because clinical manifestations of malaria only arise during the blood stage of infection, a perception exists that liver infection does not impact disease pathology. By developing a …

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A non-canonical sensing pathway mediates Plasmodium adaptation to AA deficiency

Inês M. Marreiros, Sofia Marques, Ana Parreira, Vincent Mastrodomenico et autres

Abstract Eukaryotes have canonical pathways for responding to amino acid (AA) availability. Under AA-limiting conditions, the TOR complex is repressed, whereas the sensor kinase GCN2 is activated. While these pathways have been highly conserved throughout evolution, malaria parasites are a rare exception. …

pt, us, se (code pays fourni par la source)

A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage

Amichay Afriat, Vanessa Zuzarte‐Luís, Keren Bahar Halpern, Lisa Buchauer et autres

il, pt (code pays fourni par la source)

A spatiotemporally resolved single cell atlas of the Plasmodium liver stage

Amichay Afriat, Vanessa Zuzarte‐Luís, Keren Bahar Halpern, Lisa Buchauer et autres

This code is associated with the paper "A spatiotemporally resolved single cell atlas of the Plasmodium liver stage" Data generated in this study have been deposited in Gene Expression Omnibus with the accession code GSE181725. The code used to process the raw …

il, pt (code pays fourni par la source)

A spatiotemporally resolved single cell atlas of the Plasmodium liver stage

Amichay Afriat, Vanessa Zuzarte‐Luís, Keren Bahar Halpern, Lisa Buchauer et autres

This code is associated with the paper "A spatiotemporally resolved single cell atlas of the Plasmodium liver stage" Data generated in this study have been deposited in Gene Expression Omnibus with the accession code GSE181725. The code used to process the raw …

il, pt (code pays fourni par la source)