Lifen Wen

Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection

Lifen Wen, Chun-Hsi Su, Nikita Potemkin, Lachlan Dryburgh et autres

CD4 + T helper (Th) cells are critical drivers of adaptive immunity, but how their responses are maintained during chronic infection remains unclear. Here, we identified a population of CD4 + T cells that expressed CD62L and the inhibitory receptor PD-1 and …

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MSC-small extracellular vesicles alleviated Th2-airway inflammation by regulating the metabolism of DCs in mice

Long-Xin Huang, Lifen Wen, Tian Tian, Zicong Wu et autres

BACKGROUND: Allergic airway inflammation is one of the chronic inflammatory diseases and is generally dominated by T helper 2 cells (Th2). Dendritic cells (DCs) are essential to mounting the Th2-mediated airway inflammation by presenting inhaled antigens to prime CD4+ T cells. Small …

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Deciphering mechanisms of protracted CD4 T cell responses in chronic viral infection

Lifen Wen

© 2026 Lifen Wen

The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells

Camilla Panetti, Rahel Daetwyler, Anja Moncsek, Nikolaos Patikas et autres

Abstract The co-inhibitory receptor TIGIT suppresses excessive immune responses in autoimmune conditions while also restraining antitumor immunity. In viral infections, TIGIT alone does not affect viral control but has been shown to limit tissue pathology. However, the underlying mechanisms are incompletely understood. …

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The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells

Camilla Panetti, Rahel Daetwyler, Anja Moncsek, Nikolaos Patikas et autres

The co-inhibitory receptor TIGIT suppresses excessive immune responses in autoimmune conditions while also restraining antitumor immunity. In viral infections, TIGIT alone does not affect viral control but has been shown to limit tissue pathology. However, the underlying mechanisms are incompletely understood. Here …

Lymph nodes fuel KLF2-dependent effector CD8+ T cell differentiation during chronic infection and checkpoint blockade

Carlson Tsui, Leonie Heyden, Lifen Wen, Catarina Gago da Graça et autres

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Lymph-node-derived stem-like but not tumor-tissue-resident CD8+ T cells fuel anticancer immunity

Sharanya K M Wijesinghe, Lisa Rausch, Sarah S. Gabriel, Giovanni Galletti et autres

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Supplementary effects of low-frequency transcutaneous electrical nerve stimulation on individuals with obesity combined with metabolic syndromes: study protocol for a randomised controlled trial

Yu An, Xiang Li, Xi Chen, Liuyan Wang et autres

INTRODUCTION: Obesity combined with metabolic syndrome is a major global public health problem. This trial aims to investigate the therapeutic effects of low-frequency transcutaneous electrical nerve stimulation (Lo-TENS) in individuals with obesity and coexisting metabolic syndrome. The study will also delve into …

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Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression

Catarina Gago da Graça, Amania A. Sheikh, Dane M. Newman, Lifen Wen et autres

Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying T cells with enhanced stemness and understanding their developmental requirements are of broad clinical and therapeutic interest. Here, we …

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TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf

Yinshui Chang, Luisa Bach, Marko B. Hasiuk, Lifen Wen et autres

T follicular helper (T FH ) cells are essential for effective antibody responses, but deciphering the intrinsic wiring of mouse T FH cells has long been hampered by the lack of a reliable protocol for their generation in vitro. We report that …

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Effects of noninvasive brain stimulation on dual-task performance in different populations: A systematic review

Xiaoying Lin, Yanming Zhang, Xi Chen, Lifen Wen et autres

Background: Increasing research has investigated the use of noninvasive brain stimulation (NIBS) on augmenting dual-task (DT) performance. Objective: To investigate the effects of NIBS on DT performance in different populations. Methods: Extensive electronic database search (from inception to November 20, 2022) was …

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In Vivo and In Vitro Assay to Address Dendritic Cell Antigen Cross-Presenting Capacity

Pengju Ou, Lifen Wen, Hai Ni, Cliff Y. Yang

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