Longyan Ran

Development and validation of pathomics signature for predicting prognosis of advanced high-grade serous ovarian carcinoma patients after platinum-based chemotherapy

Zhenhong Pu, Kaiting Long, Longyan Ran, Jianglong Feng et autres

In patients with advanced high-grade serous ovarian carcinoma (HGSOC), the standard treatment typically involves platinum-based chemotherapy after debulking surgery. However, the prognosis of patients following platinum-based chemotherapy varies, and known prognostic factors do not fully explain this variability. Therefore, developing an accurate …

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Tide: Intra- and Inter-Timeslot Enhanced Node Embedding for Probing Attack Detection in SDN

Longyan Ran, Yunhe Cui, Guowei Shen, Chun Guo et autres

Probing the configurations of the Software-Defined Networking (SDN) switches is the essential preliminary for attacking SDN. This study points out a critical bottleneck in detecting probing attack: the dynamically changing character of different kinds of probing attacks makes the existing detection methods …

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Socioeconomic status and intrinsic capacity trajectories among middle-aged and older adults in China: mediating role of cognitive leisure activities

MingYan ming Qing, Jiang lan Wang, Lu Wang, Linyan Xie et autres

OBJECTIVES: This study aimed to examine the association between socioeconomic status (SES) and intrinsic capacity (IC) trajectories among Chinese adults aged ≥45 years and evaluate the mediating role of cognitive leisure activities (CLA) on this relationship. DESIGN: A cohort study. SETTING AND …

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Correction: ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma

Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li et autres

In Figure 3E, as a result of a file labelling error, inappropriate images were selected for the 0h and 24h conditions. In Figure 3G, inappropriate image selection resulted in a partial overlap in the siRNA ADORA2A-2 and siRNA ADORA2A-3 conditions in SW620 …

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Towards Saturation Attack Detection in SDN: A Device Hyperedge Graph and Flow-Device Hypergraph Neural Network-Based Method

Longyan Ran, Yunhe Cui, Guowei Shen, Qing Qian

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TITAN: Combining a bidirectional forwarding graph and GCN to detect saturation attack targeted at SDN

Longyan Ran, Yunhe Cui, Jianpeng Zhao, Hongzhen Yang

The decoupling of control and forwarding layers brings Software-Defined Networking (SDN) the network programmability and global control capability, but it also poses SDN security risks. The adversaries can use the forwarding and control decoupling character of SDN to forge legitimate traffic, launching …

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ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma

Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li et autres

The third most often diagnosed disease globally and the second most prevalent cause of cancer-related death is colorectal cancer (CRC). Numerous human malignancies have been identified to have high expression of ADORA2A. However, it is still ambiguous about its function in CRC. …

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Silencing MARCH2 Inhibits the Invasion, Migration, and EMT Transformation of Human Colorectal Cancer SW480 Cells

Yun Liu, Longyan Ran, Qingxi Guo, Pu Xia et autres

Aim: This study aimed to investigate the role of MARCH2 (membrane-associated RING-CH2) in the progression, invasion, and migration of colorectal cancer (CRC). Methods: In this study, the expression levels of MARCH2 and E-cadherin in CRC tissues were detected by immunohistochemistry through retrospective …

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ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma

Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li et autres

Abstract Background：The third most often diagnosed disease globally and the second most prevalent cause of cancer-related death is colorectal cancer (CRC). Numerous human malignancies have been identified to overexpress ADORA2A. However, it is still ambiguous about its function in CRC. Methods: RNA-seq …

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Author response for "Silencing MARCH2 Inhibits the Invasion, Migration, and EMT Transformation of Human Colorectal Cancer SW480 Cells"

Yun Liu, Longyan Ran, Qing‐Xi Guo, Xia Pu et autres

C5aR1 promotes the progression of colorectal cancer by EMT and activating Wnt/β-catenin pathway

Duo Xu, Meirong Li, Longyan Ran, Xiaochen Li et autres

BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant cancers in human, and its incidence increases gradually every year. Metastasis is an important factor leading to tumor development. The epithelial-mesenchymal transition (EMT) has been proved to be closely related to …

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Defending saturation attacks on SDN controller: A confusable instance analysis-based algorithm

Longyan Ran, Yunhe Cui, Chun Guo, Qing Qian et autres

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