Young K. Park

Evaluation of Antigen Expression and Early Immune Response following Cutaneous Suction-mediated DNA Delivery

Nandita Chakrabarty Jhumur, Yukyung Um, Sarah H. Park, Emran O. Lallow et autres

Suction-based in vivo cutaneous DNA transfection is a newly developed, cost-effective method that produces high transfection efficiency. This method has shown robust immunogenic responses following SARS-CoV-2 DNA vaccination in both pre-clinical studies and clinical trials. The current work investigates suction-based transfection and …

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Immunogenicity and protection of a triple repeat domain III mRNA vaccine against Zika virus

Yu‐Sun Lee, Mi Sun Cheong, Jisun Lee, Eun‐Kyoung Bang et autres

Zika virus (ZIKV) infection is primarily transmitted by mosquitoes and often asymptomatic in most individuals. Infection during pregnancy can lead to severe birth defects such as congenital microcephaly, and currently, there is no approved vaccine for ZIKV. Several studies are investigating the …

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An overview of SARS-CoV-2 viral proteins with relevance to improved diagnostic and therapeutic platforms

Christopher W. Chung, Pratiba Irudayaraj, Emran O. Lallow, Ziyang Xu et autres

In the past 25 years, the world has witnessed outbreaks of illnesses in humans from three different coronaviruses. Both the SARS-CoV outbreak of 2003 and the MERS-CoV outbreak of 2013 resulted in overall low fatalities in part due to inefficient human-to-human spread …

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Tissue Tension and Strain as Indicators of Suction‐mediated Cutaneous DNA Transfection: A Parametric Study

Nandita Chakrabarty Jhumur, Emran O. Lallow, Catherine J. Nachtigal, Dahee Yeo et autres

Abstract Cutaneous suction‐based transfection is a recently developed technique that is painless and simple‐to‐use for the delivery of DNA for nucleic‐acid‐based vaccines. The technique promises high efficiency for both antigen expression and immunogenicity as demonstrated in both animal studies and human clinical …

us, kr (code pays fourni par la source)

Tissue Tension and Strain as Indicators of Suction-mediated Cutaneous DNA Transfection: A Parametric Study

Nandita Chakrabarty Jhumur, Emran O. Lallow, Catherine J. Nachtigal, Dahee Yeo et autres

Cutaneous suction-based transfection is a recently developed technique that is painless and simple-to-use for the delivery of DNA for nucleic-acid-based vaccines. The technique promises high efficiency for both antigen expression and immunogenicity as demonstrated in both animal studies and human clinical trials. …

kr (code pays fourni par la source)

Immunogenicity and Protection of a Triple Repeat Domain Iii Mrna Vaccine Against Zika Virus

Yu‐Sun Lee, Mi Sun Cheong, Jisun Lee, Eun‐Kyoung Bang et autres

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Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in Immunotherapy

Christopher W. Chung, Sagar B. Kudchodkar, Curtis N. Chung, Young K. Park et autres

Harnessing the immune system to combat disease has revolutionized medical treatment. Monoclonal antibodies (mAbs), in particular, have emerged as important immunotherapeutic agents with clinical relevance in treating a wide range of diseases, including allergies, autoimmune diseases, neurodegenerative disorders, cancer, and infectious diseases. …

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Immune response enhancement with GLS-5310 DNA primary vaccine against SARS-CoV-2 followed by administration of an mRNA vaccine heterologous boost

Woo Joo Kim, Christine C. Roberts, Joon Young Song, Jin Gu Yoon et autres

Heterologous boost regimens are being increasingly considered against SARS-CoV-2. We report results for the 32 of 45 participants in the Phase 1 CoV2-001 clinical trial (Kim et al., Int J Iinfect Dis 2023, 128:112-120) who elected to receive an EUA-approved SARS-CoV-2 mRNA …

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DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond

Joel N. Maslow, Ijoo Kwon, Sagar B. Kudchodkar, D. M. Kane et autres

We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines …

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Molecular distribution in intradermal injection for transfer and delivery of therapeutics

Emran O. Lallow, Kishankumar J. Busha, Sarah H. Park, Maria Atzampou et autres

Intradermal (ID) injection is a technique widely used in laboratorial and clinical applications. The boundary of the dome-like bleb formed during injection is assumed to represent the lateral extent of the injected material. This work systematically characterizes cargo molecule distribution (puddle) as …

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Safety and immunogenicity of the bi-cistronic GLS-5310 COVID-19 DNA vaccine delivered with the GeneDerm suction device

Woo Joo Kim, Christine C. Roberts, Joon Young Song, Jin Gu Yoon et autres

Objectives The CoV2-001 phase I randomized trial evaluated the safety and immunogenicity of the GLS-5310 bi-cistronic DNA vaccine through 48 weeks of follow-up. Design A total of 45 vaccine-naïve participants were recruited between December 31, 2020, and March 30, 2021. GLS-5310, encoding …

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Characterization of a small molecule modulator of inflammatory cytokine production

Sagar B. Kudchodkar, Paolo Fagone, Omkar Uday Kawalekar, Moonsup Jeong et autres

Abstract In the present study, the effect(s) of the immunomodulatory drug GLS-1027 on various cell types involved in inflammation were investigated. GLS-1027 reduced LPS-stimulated secretion of pro-inflammatory cytokines by macrophage or monocytic cells and cell lines. This reduction was likely due in …

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