Donald Y.M. Leung

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

J. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai et autres

INTRODUCTION: Atopic Dermatitis (AD) is a chronic inflammatory skin disease characterized by complex pathogenesis, variable clinical phenotypes, and broad severity spectrum. We utilized a serum-proteomic approach integrated with machine learning (ML) to identify novel biomarkers that distinguish mild from severe AD. METHODS: …

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Skin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients

Taras Lyubchenko, Evgeny Berdyshev, Ryan Weight, Olivia Xiao et autres

BACKGROUND: Immune-related cutaneous adverse events (ircAEs) complicate management in many cancer patients receiving checkpoint inhibitor (CPI) immunotherapy. A new approach to early prognosis and ircAE treatment monitoring is needed in order to improve patient adherence to CPI immunotherapy. METHODS: Skin tape strips …

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Observations on emergence of mannitol-use-deficient Staphylococcus aureus

Patrick M. Schlievert, Samuel H. Kilgore, Takeshi Yoshida, Lisa A. Beck et autres

ABSTRACT Staphylococcus aureus clones emerge and recede in roughly 10-year intervals unless virulence factors impose clonal continuation. This study investigates a newly emergent clone. Prior to 2020, all of 322 clinical isolates tested grew, as expected, yellow colonies on mannitol salt agar. …

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297 Trajectory AD Severity Modeling to Better Define Dupilumab Response: A Framework for Precision Biomarker Discovery

J. Lally, Xueting Zhang, Takeshi Yoshida, Elena Goleva et autres

Update on atopic dermatitis

Donald Y.M. Leung

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Predictive biomarkers for atopic dermatitis

Jessica Hui, Elena Goleva, Donald Y.M. Leung

The discovery of early-life preclinical biomarkers for atopic dermatitis (AD) is an important area of research to prevent AD development and introduce treatment measures early to reduce AD severity. Birth cohort studies performed worldwide have given insights into skin barrier components, such …

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S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis

Mrinmoy Das, Mohammed Alasharee, Brian Woods, Saikat Mukherjee et autres

The mechanism of the association of S. aureus skin colonization with food allergy in atopic dermatitis (AD) is unknown. Interleukin-4 (IL-4) plays an important role in food allergy. We found elevated serum IL-4 concentrations in AD patients with S. aureus skin colonization …

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Author response for "Predictive biomarkers for atopic dermatitis"

Jessica Hui, Elena Goleva, Donald Y.M. Leung

63413 Dupilumab Treatment Improves Skin Barrier Function in Adolescent and Adult Patients With Atopic Dermatitis: Results From the BALISTAD and BALISTAD-CN Studies

Robert Bissonnette, Taoming Liu, Yunsheng Liang, Elena Goleva et autres

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Early Predictors of Atopic Dermatitis and Food Allergy

Myongsoon Sung, Byung Eui Kim, Donald Y.M. Leung

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Response to: “Response to Bissonnette et al. Dupilumab treatment restores lesional and nonlesional skin barrier function in adults and adolescents with atopic dermatitis irrespective of the filaggrin genotype: Results from an open-label, healthy control–matched, phase 4 clinical study (BALISTAD)”

Robert Bissonnette, Elena Goleva, Evgeny Berdyshev, Donald Y.M. Leung

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0490 Proteomic analysis reveals sustained improvements in skin composition in pediatric patients treated with dupilumab

E. Goleva, E. Berdyshev, S. Kreimer, T. Lyubchenko et autres