Accès ouvert
2019
conference-abstract
OpenAlex
Sista Sugiarto, Robin Gillmore Lerner, Brian Reichholf, Martin McMahon et autres
Expression of the constitutively active BRAFV600E-mutant kinase occurs in pediatric and predominantly young adult high-grade glioma patients (Cancer Res. 2010, 70:512; Acta Neuropathol. 2011, 121:397). BRAFV600E expression frequently coincides with CDKN2A deletion and marks a subgroup of predominantly hemispheric tumors with epigenetic …
gb, at, us
(code pays fourni par la source)
2014
article
OpenAlex
Huibin Tang, Ken Inoki, Myung Jong Lee, Erika Wright et autres
Skeletal muscle mass and function are regulated by motor innervation, and denervation results in muscle atrophy. The activity of mammalian target of rapamycin complex 1 (mTORC1) is substantially increased in denervated muscle, but its regulatory role in denervation-induced atrophy remains unclear. At …
us
(code pays fourni par la source)
Accès ouvert
2014
article
OpenAlex
Huibin Tang, Ira J. Smith, Sabah N. A. Hussain, Peter Goldberg et autres
Mechanical ventilation (MV) is one of the lynchpins of modern intensive-care medicine and is life saving in many critically ill patients. Continuous ventilator support, however, results in ventilation-induced diaphragm dysfunction (VIDD) that likely prolongs patients' need for MV and thereby leads to …
us, ca
(code pays fourni par la source)
2013
conference-abstract
OpenAlex
Robin Gillmore Lerner, Yuichiro Ihara, Brian Reichholf, Dian Qu et autres
Abstract Within the adult mammalian brain the asymmetric distribution of cell-fate determinants during mitosis maintains a balance between differentiated and self-renewing cells. We have previously shown that disruption of asymmetric divisions in oligodendrocyte progenitor cells (OPC) causes cells to aberrantly self-renew and …
2012
conference-abstract
OpenAlex
Claudia Katharina Petritsch, Sista Sugiarto, Anders I. Persson, William A. Weiss
Abstract Mammalian oligodendrocyte progenitors expressing the chondroitine sulfate proteoglycan NG2 are the largest dividing population in the postnatal, mammalian brain. NG2+ oligodendrocyte progenitors self-renew and generate mature oligodendrocytes. The mechanism by which oligodendrocyte progenitors fulfill their dual function has been unclear. NG2+ …
us
(code pays fourni par la source)
Accès ouvert
2011
article
OpenAlex
Sista Sugiarto, Anders I. Persson, Elena González-Muñoz, Markus Waldhuber et autres
us, de
(code pays fourni par la source)