Nathalie Wrobel

Meta-analytic evidence for distinct neural correlates of conditioned versus verbally induced placebo analgesia

Tamás Spisák, Helena Hartmann, Matthias Zunhammer, Bálint Kincses et autres

Placebo analgesia demonstrates that belief and expectation can significantly alter pain, even without active treatment. Placebo analgesia can be induced through verbal suggestion, classical conditioning, or their combination, though the role of conditioned neural responses above and beyond effects of verbal instructions …

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Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

Matthias Zunhammer, Tamás Spisák, Tor D. Wager, Ulrike Bingel et autres

The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We …

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Emotional Instability Relates to Ventral Striatum Activity During Reward Anticipation in Females

Frida Bayard, Christoph Abé, Nathalie Wrobel, Martin Ingvar et autres

Both non-emotional symptoms, such as inattention, and symptoms of emotional instability (EI) are partially co-varying and normally distributed in the general population. ADHD, which is associated with both inattention and emotional instability, has been related to lower reward anticipation activation in ventral …

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Conditioned pain modulation in drug-naïve patients with de novo Parkinson’s disease

Wiebke Grashorn, Odette Fründt, Carsten Buhmann, Nathalie Wrobel et autres

BACKGROUND: Pain is highly prevalent in patients with Parkinson's disease (PD), but underlying pathophysiological mechanisms are largely unclear. In many chronic pain syndromes deficits in endogenous pain inhibition have been detected that can be assessed using conditioned pain modulation paradigms. Previous studies …

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Pain in Parkinson disease: a cross-sectional survey of its prevalence, specifics, and therapy

Carsten Buhmann, Nathalie Wrobel, Wiebke Grashorn, Odette Fruendt et autres

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Quantitative Sensory Testing in adults with Autism Spectrum Disorders

Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker et autres

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Preserved Capacity for Placebo Analgesia in the Elderly

Nathalie Wrobel, Tahmine Fadai, Stefanie Brassen, Ulrike Bingel

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Are Children the Better Placebo Analgesia Responders? An Experimental Approach

Nathalie Wrobel, Tahmine Fadai, Christian Sprenger, Johannes Hebebrand et autres

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Haloperidol blocks dorsal striatum activity but not analgesia in a placebo paradigm

Nathalie Wrobel, Katja Wiech, Katarina Forkmann, Christoph Ritter et autres

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Minimizing Carry-Over Effects After Treatment Failure and Maximizing Therapeutic Outcome

Mareile Hofmann, Nathalie Wrobel, Simon S. Kessner, Ulrike Bingel

According to experimental and clinical evidence, the experiences of previous treatments are carried over to different therapeutic approaches and impair the outcome of subsequent treatments. In this behavioral pilot study we used a change in administration route to investigate whether the effect …

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Effect of Oxytocin on Placebo Analgesia

Simon S. Kessner, Christian Sprenger, Nathalie Wrobel, Katja Wiech et autres

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Age-Dependent Decline of Endogenous Pain Control: Exploring the Effect of Expectation and Depression

Wiebke Grashorn, Christian Sprenger, Katarina Forkmann, Nathalie Wrobel et autres

Although chronic pain affects all age ranges, it is particularly common in the elderly. One potential explanation for the high prevalence of chronic pain in the older population is impaired functioning of the descending pain inhibitory system which can be studied in …

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