Accès ouvert
2026
article
OpenAlex
Marco Fumagalli, Giulia Martinelli, Silvio Sosa, Zixiong Tang et autres
Abstract Background Sumac ( Rhus coriaria L., Anacardiaceae) fruit is receiving a growing attention as potential nutraceutical and cosmetic ingredient. It is appreciated either as a spice and medicinal remedy in Middle East countries. The application of fruits preparations to skin injuries …
it
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Accès ouvert
2026
article
OpenAlex
A. Altomare, Giovanna Baron, Francesca Gado, Larissa Della Vedova et autres
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (HNE), which has been detected in previous …
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Accès ouvert
2026
article
OpenAlex
Simone Manzi, Alessandra Altomare, Giacomo Mosconi, Maria Serena Rossitto et autres
High Resolution Image Download MS PowerPoint Slide Hyaluronic acid (HA) plays key roles in tissue hydration, repair, and cellular signaling. Its quantification in biological matrices is crucial but challenging due to its endogenous nature and poor mass spectrometric detectability. We developed a …
it
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Accès ouvert
2026
article
OpenAlex
Giulio Ferrario, Daniela Impellizzeri, Giovanna Baron, Ramona D’Amico et autres
Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease (IBD) with increasing incidence worldwide. Current treatments, including NSAIDs and corticosteroids, provide partial symptom relief but are associated with significant side effects, highlighting the need for novel therapies with improved safety profiles. Given …
it
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Accès ouvert
2025
article
OpenAlex
Giulia Martinelli, Nicole Maranta, Giovanna Nicotra, Silvia Francesca Vicentini et autres
ETHNOPHARMACOLOGICAL RELEVANCE: Cistus x incanus L. is a Mediterranean plant traditionally used to treat infective conditions, including urinary tract infections (UTI). However, experimental validation against uropathogenic Escherichia coli (UPEC) is limited. AIM OF THE STUDY: To investigate the antibacterial and anti-inflammatory effects …
it
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Accès ouvert
2025
article
OpenAlex
Taynara Aparecida Vieira, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Núbia Alves Grandini et autres
Inflammation is associated with the pathogenesis of obesity-related disorders, including cardiac remodeling. Bergamot is known for its promising anti-inflammatory effects. Thus, this study aimed to investigate the anti-inflammatory effect of bergamot leaves extract (BLE) in attenuating cardiac remodeling in obese rats through …
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2025
article
OpenAlex
Luciano D’Apolito, Antonio Miele, Yoko Suzumoto, Anna Iervolino et autres
Abstract Background and Aims Hypertension (HT) is a complex and heterogeneous pathological condition: the interaction between genetic and environmental factors leads to an increase in blood pressure (BP). HT represents a risk factor for cardiovascular disease and the major cause of mortality …
it
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Accès ouvert
2025
article
OpenAlex
Larissa Della Vedova, Giovanna Baron, Paolo Morazzoni, Sandro Santinello et autres
Background: The sustainable use of agro-industrial by-products is essential to reduce environmental impact and enhance resource efficiency. In this study, white grape skins (WGSs), a distillation by-product of grappa production, are valorized through the development of an eco-friendly extraction process. Methods: At …
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Accès ouvert
2025
article
OpenAlex
Taynara Aparecida Vieira, Danielle Gabriel Seloto, Joyce Santana Rizzi, Paloma Vitória Lima Peixoto et autres
) leaves yield a high level of antioxidant polyphenolic compounds that may hinder the development of liver diseases, while their potential is yet to be fully explored. Thus, the aim of the study was to test the effects of bergamot leaf extract …
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Accès ouvert
2025
article
OpenAlex
Fabrizio Araniti, Giovanna Baron, Giulio Ferrario, Michele Pesenti et autres
This pilot study investigates the chemical profiling and antioxidant potential of six blueberry genotypes: three tetraploids from the highbush blueberry species and three hexaploids from the rabbiteye blueberry species. The goal was to characterise the biochemical composition of these genotypes, grown under …
it
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Accès ouvert
2025
article
OpenAlex
Larissa Della Vedova, Giovanna Baron, Paolo Morazzoni, Giancarlo Aldini et autres
Background: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging and the progression of age-related diseases. Senotherapeutics, …
it
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Accès ouvert
2025
article
OpenAlex
Rebecca Ferrisi, Beatrice Polini, Anna Maria Smolyakova, Chiara Migone et autres
The design of dualsteric/bitopic receptor ligands as compounds capable of simultaneously interacting with both the orthosteric and an allosteric binding site has gained importance to achieve enhanced receptor specificity and minimize off-target effects. In this work, we reported the synthesis and biological …
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