Veronica Ilie

Phenotypic Assessment of Liver-Derived Cell Cultures during in vitro Expansion

Razvan Andrei Iacob, Vlad Herlea, Lorand Savu, Ioana Raluca Florea et autres

Background: Liver cells represent an attractive source of cells for autologous regenerative medicine. The present study assesses the liver cells’ stability during in vitro expansion, as a prerequisite for therapeutic use. Results: The human liver cell cultures in this study were propagated …

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The Effect of Liver Donors’ Age, Gender and Metabolic State on Pancreatic Lineage Activation

I Matei, Irit Meivar‐Levy, Daniela Lixandru, Simona Dima et autres

Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors’ heterogeneity with regard to age, …

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Tu1612 FOXA2 EXPRESSION IS SIGNIFICANTLY ASSOCIATED WITH DIFFERENTIATION AND PROGNOSTIC FEATURES IN PANCREATIC DUCTAL ADENOCARCINOMA

Razvan Andrei Iacob, Mihaela Uta, Ioana Manea, Speranța Iacob et autres

miRNA 200 Family Expression is a Strong Predictor for Recurrence Following Liver Resection for Breast Cancer Liver Metastases

Nicolae Bacalbașa, Irina Bălescu, Veronica Ilie, Raluca Florea et autres

Although only a small percent of breast cancer patients are diagnosed in metastatic stages, a significantly higher percent will develop disseminated recurrences at a certain point of their evolution, this event being responsible for a high number of cancer relate deaths.In recent …

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The Impact on the Long-term Outcomes of Hormonal Status After Hepatic Resection for Breast Cancer Liver Metastases

Nicolae Bacalbașa, Irina Bălescu, Veronica Ilie, Raluca Florea et autres

BACKGROUND/AIM: Breast cancer remains one of the most frequently encountered malignancies worldwide, which is in most cases diagnosed in early stages of disease. However, although surgery and adjuvant oncological treatment are performed with curative intent, a certain number of cases will develop …

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The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

Cristian‐Mihail Niculae, Eliza Manea, Simona Merișor, Ruxandra Moroti et autres

BackgroundBacteriophages are hypothesized to contribute to biofilm eradication through multiple actions, such as: 1) amplification in host cells; 2) production of depolymerizing enzymes that degrade the matrix of extracellular polymeric substances; 3) induction of depolymerizing enzymes in host cells; 4) infection of …

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Gene-expression Profiling in Non-small Cell Lung Cancer with Invasion of Mediastinal Lymph Nodes for Prognosis Evaluation.

Mădălina Grigoroiu, Rebecca Tagett, Sorin Drăghici, Simona Dima et autres

BACKGROUND/AIM: The aim of the study was to determine the pathways and expression profile of the genes that might predict response to neoadjuvant chemotherapy in patients with stage IIIA non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We evaluated, by microarray, the …

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Molecular factors involved in β-catenin gene overexpression in pancreatic cancer

Adelina Botezatu, Iulia Virginia Iancu, Gabriela Anton, Carmen Cristina Diaconu et autres

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S100A4 and ERBB2 as Co-Factors in Pancreatic Cancer

Anca Năstase, Simona Dima, Valeria Ţică, Raluca Florea et autres

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive tumors with dismal prognosis and survival rates.Identifying early molecular diagnostic markers could contribute in improving survival in this intractable disease.Chromosomal rearrangements and altered expression of the gene have been implicated in …

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Deregulation B-Catenin Gene Expression in Pancreatic Cancer

Adelina Botezatu, Iulia Virginia Iancu, Adriana Pleșa, Carmen Cristina Diaconu et autres

Assessment of bacteriophage activity against local strains of Enterococcus and Pseudomonasin Romania

Alina Cristina Neguț, Oana Săndulescu, Anca Streinu‐Cercel, Zemphira Alavidze et autres

Enterococcus faecium and Pseudomonas aeruginosa are part of the ESCAPE pathogens, which have the ability to “escape” the currently available therapeutic options. For these germs alternatives are needed, as is the case of bacteriophage treatment. In this study we used a bacteriophage …

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Gene Expression of Hepatocellular Carcinoma Reveals Glypican-3 Role as Potential Biomarker

Anca Năstase, Nicolae Bacalbașa, Veronica Ilie, Raluca Florea et autres

Aim: To assess gene expression of glypican-3 in patients with hepatocellular carcinoma and in HUH7 cell lines treated with doxorubicin and to evaluate its role as early potential biomarker. Material and methods: Tissue samples from 30 patients (liver transplant, n=18, liver resection, …