Rosario Musumeci

Resistance to Human-Reserved Antimicrobials in Clinical and Commensal Enterococcus faecalis and Enterococcus faecium from Dogs and Cats

Giulia Iamone, Alessandro Bellato, Ilaria Prandi, Maria Cristina Stella et autres

Background/Objectives: Although companion animals are recognized as reservoirs of antimicrobial resistant enterococci, it remains unclear whether antimicrobial resistance differs between clinical and commensal isolates, particularly for antimicrobials reserved for human medicine. This study compared antimicrobial susceptibility profiles of clinical and commensal E. …

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Toward a unified approach: Considerations for bioinformatic and sequencing activities & data in wastewater surveillance of biologic public health threats

Fotis Psomopoulos, Colman O’Cathail, Natasa Anastasiadou, Clementina Cocuzza et autres

Genomic technologies such as PCR and next-generation sequencing (NGS) have greatly advanced public health surveillance, especially during COVID-19, by enabling detailed tracking of pathogen spread, origins, and variants. While PCR is vital for targeted detection, falling NGS costs have made large-scale, high-throughput …

The SIS NET ICU study: characteristics of patients with severe community acquired pneumonia admitted to Italian ICUs—a multicenter prospective observational study

Mariachiara Ippolito, Giulia Catalisano, Matteo Velardo, Marina Campione et autres

BACKGROUND: The SIS-NET ICU study aimed to describe the epidemiology of severe community-acquired pneumonia (CAP) among patients admitted to Italian intensive care units (ICUs). This study also aimed to describe the clinical and microbiological characteristics, outcomes, and treatments received by the included …

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Toward a unified approach: Considerations for bioinformatic and sequencing activities & data in wastewater surveillance of biologic public health threats

Fotis Psomopoulos, Colman O’Cathail, Natasa Anastasiadou, Clementina Cocuzza et autres

Genomic technologies like PCR and next-generation sequencing (NGS) have greatly advanced public health surveillance, especially during COVID-19, by enabling detailed tracking of pathogen spread, origins, and variants. While PCR is vital for targeted detection, falling NGS costs have made large-scale, high-throughput sequencing …

Evaluating Interlaboratory Variability in Wastewater-Based COVID-19 Surveillance

Arianna Azzellino, Laura Pellegrinelli, Ramon Pedrini, Andrea Turolla et autres

Wastewater-based environmental surveillance enables the monitoring of SARS-CoV-2 dynamics within populations, offering critical epidemiological insights. Numerous workflows for tracking SARS-CoV-2 have been developed globally, underscoring the need for interlaboratory comparisons to ensure data consistency and comparability. An inter-calibration test was conducted among …

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In Vitro Preliminary Evaluation of a New Rifamycin In Situ Gelling Formulation for Pouchitis Treatment

Caterina Aiello, Cinzia Quattrocchi, Rosario Musumeci, Daria Nicolosi et autres

Pouchitis is one of the most common long-term complications after ileal pouch–anal anastomosis (IPAA) surgery, with a reported incidence rate of up to 50%. Identifying specific bacteria involved in the pathogenesis has important implications for clinical management. Indeed, antibiotic therapy is a …

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Molecular Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Pathogens in Cervical and Self-Collected Specimens

Chiara Giubbi, Marianna Martinelli, Michelle Rizza, Maria Letizia Di Meo et autres

This study investigated the detection of high-risk Human Papillomavirus (hrHPV) and seven other pathogens associated with sexually transmitted infections (STIs) in matched clinician-collected cervical samples and self-taken vaginal and urine specimens collected from 342 asymptomatic women referred to colposcopy to evaluate (i) …

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Wastewater Surveillance for SARS-CoV-2 in Northern Italy: An Evaluation of Three Different Gene Targets

Giulio Mannarà, Marianna Martinelli, Chiara Giubbi, Michelle Rizza et autres

Wastewater-based epidemiology has emerged as a complementary tool for the monitoring of COVID-19 pandemic waves and for the circulation of viral variants. The selection, standardization, and dynamics of different SARS-CoV-2 RNA targets in wastewater requires further investigation. In the present study, 106 …

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Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020)

Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo et autres

OBJECTIVES: Although antimicrobial resistance has not yet emerged as an overarching problem for Legionella pneumophila (L. pneumophila) infection, the description of clinical and environmental strains resistant to fluoroquinolones and macrolides is a cause of concern. This study aimed to investigate the antimicrobial …

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Toward a unified approach: Considerations for bioinformatic and sequencing activities & data in wastewater surveillance of biologic public health threats.

Fotis Psomopoulos, Colman O’Cathail, Natasa Anastasiadou, Clementina Cocuzza et autres

Genomic technologies such as PCR and next-generation sequencing (NGS) have greatly advanced public health surveillance, especially during COVID-19, by enabling detailed tracking of pathogen spread, origins, and variants. While PCR is vital for targeted detection, falling NGS costs have made large-scale, high-throughput …

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Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Pathogens in Cervical and Self-Collected Specimens of Women Referred to Colposcopy

Chiara Giubbi, Marianna Martinelli, Michelle Rizza, Maria Letizia Di Meo et autres

High-risk Human Papillomavirus (hrHPV) persistent infection is acknowledged as the primary cause of cervical cancer. Coinfection with other sexually transmitted infections (STIs) may be associated with a higher risk of cervical lesion progression. This study investigated the detection of hrHPV and 7 …

Tracking the Spread of the BA.2.86 Lineage in Italy Through Wastewater Analysis

Carolina Veneri, David Brandtner, Pamela Mancini, Giusy Bonanno Ferraro et autres

The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This …

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