Ivonne Regel

Immunreaktion in Tumoren: neue Ansätze zur Früherkennung des Pankreaskarzinoms

Ivonne Regel, Jonas Rosendahl

Das Pankreaskarzinom, insbesondere das pankreatische duktale Adenokarzinom (PDAC), zählt mit einer 5‑Jahres-Überlebensrate von ca. 13 % zu den aggressivsten Tumorerkrankungen. Die schlechte Prognose ist v. a. auf die späte Diagnosestellung zurückzuführen, da frühe Stadien häufig asymptomatisch sind. Vorläuferläsionen und Risikofaktoren sind zwar …

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Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment

Ahmed Alnatsha, Jianying Xu, Tahib Habshi, Qi Li et autres

Background As key constituents of cellular sphingolipid pools, sphingomyelin (SM) and ceramide (CER) are central to the regulation of cancer cell death and survival. The metabolic flux between these two lipids is a vital component of the cellular stress response, yet the …

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Supplementary Figure 6 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

ROR2 promotes EMT and stemness.

Supplementary Figure 7 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

ROR2 regulates cell proliferation.

Supplementary Figure 2 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

ROR2 is associated with gastric identity.

Supplementary Figure 3 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

Ror2 is expressed in pancreatic meta/neoplastic lesions with a gastric neck/SPEM cell-like identity.

Supplementary Figure 5 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

The pit cell-like and the classical PDAC signature show a tight overlap.

Supplementary Figure 4 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

Ablation of Ror2 promotes tissue transformation.

Supplementary Figure 1 from ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Simone Benitz, Alec Steep, Malak Nasser, Jonathan Preall et autres

Using snATAC-seq to study early transformation of the pancreas.

Rituximab limits glucocorticoid use in IgG4-related disease: Real-world evidence from a large European cohort

Jens Vikse, M. Lanzillotta, Elisabetta Goni, Bjørg-Tilde Svanes Fevang et autres

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NLRP3 Inflammasome Activation‐Induced Acute Papillitis as a Trigger of Acute Pancreatitis ‐ A Novel Mechanism of Microlithiasis‐Induced Acute Pancreatitis

Simon Sirtl, Mahmood Ahmad, Prince Allawadhi, Thomas J. Metzler et autres

INTRODUCTION: Obstruction of the pancreatic duct by impacted gallstones at the level of the papilla vateri causes acute pancreatitis. How non-obstructing stones such as microlithiasis or sludge cause pancreatitis has not been studied. We aimed to understand the pathomechanism of microlithiasis-induced acute …

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STING Ablation in T Cells Is Required for the Efficacy of STING Agonists in CAR-T Cell Immunotherapy of Pancreatic Cancer

Ignazio Piseddu, Rebekka Endres, Fabian Lanzl, Linda Hammann et autres

BACKGROUND & AIMS: Chimeric antigen receptor (CAR) T cells have shown great potential in hematological cancers, but lack efficacy in solid tumors, highlighting the need for novel strategies. Stimulator of interferon genes (STING) activation was shown to inflame the tumor microenvironment, but …

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