Elham Bayat Mokhtari

Filtering ASVs/OTUs via mutual information-based microbiome network analysis

Elham Bayat Mokhtari, Benjamin J. Ridenhour

Microbial communities are widely studied using high-throughput sequencing techniques, such as 16S rRNA gene sequencing. These techniques have attracted biologists as they offer powerful tools to explore microbial communities and investigate their patterns of diversity in biological and biomedical samples at remarkable …

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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Kathryn McGuckin Wuertz, Erica K. Barkei, Wei‐Hung Chen, Elizabeth J. Martinez et autres

The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the Alpha (B.1.1.7), and Beta (B.1.351) VOCs …

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mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

Kizzmekia S. Corbett, Anne P. Werner, Sarah O’ Connell, Matthew Gagné et autres

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Infection and Vaccine-Induced Neutralizing-Antibody Responses to the SARS-CoV-2 B.1.617 Variants

Venkata-Viswanadh Edara, Benjamin A. Pinsky, Mehul S. Suthar, Lilin Lai et autres

To assess infection and vaccine-Induced Neutralizing-Antibody activity against the SARS-CoV-2 B.1.617.1 (or kappa) and B.1.617.2 (or delta) variants.

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Decoding influenza outbreaks in a rural region of the USA with archetypal analysis

Elham Bayat Mokhtari, Erin L. Landguth, Stacey Anderson, Emily Stone

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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

Kathryn McGuckin Wuertz, Erica K. Barkei, Wei-hung Chen, Elizabeth J. Martinez et autres

The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian golden …

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Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

Kizzmekia S. Corbett, Anne P. Werner, Sarah O’ Connell, Matthew Gagné et autres

ABSTRACT Background Vaccine efficacy against the B.1.351 variant following mRNA-1273 vaccination in humans has not been determined. Nonhuman primates (NHP) are a useful model for demonstrating whether mRNA-1273 mediates protection against B.1.351. Methods Nonhuman primates received 30 or 100 µg of mRNA-1273 …

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Infection and vaccine-induced neutralizing antibody responses to the SARS-CoV-2 B.1.617.1 variant

Venkata Viswanadh Edara, Lilin Lai, Malaya K. Sahoo, Katharine Floyd et autres

SARS-CoV-2 has caused a devastating global pandemic. The recent emergence of SARS-CoV-2 variants that are less sensitive to neutralization by convalescent sera or vaccine-induced neutralizing antibody responses has raised concerns. A second wave of SARS-CoV-2 infections in India is leading to the …

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High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

Sung Hee Ko, Elham Bayat Mokhtari, Prakriti Mudvari, Sydney Stein et autres

Tracking evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within infected individuals will help elucidate coronavirus disease 2019 (COVID-19) pathogenesis and inform use of antiviral interventions. In this study, we developed an approach for sequencing the region encoding the SARS-CoV-2 …

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Filtering ASVs/OTUs via Mutual Information-Based Microbiome Network Analysis

Elham Bayat Mokhtari, Benjamin J. Ridenhour

Microbial communities are widely studied using high-throughput sequencing techniques, such as 16S rRNA gene sequencing. These techniques have attracted biologists as they offer powerful tools to explore microbial communities and investigate their patterns of diversity in biological and biomedical samples at remarkable …

High-Throughput, Single-Copy Sequencing Reveals SARS-CoV-2 Spike Variants Coincident with Mounting Humoral Immunity during Acute COVID-19

Sung Hee Ko, Elham Bayat Mokhtari, Prakriti Mudvari, Sydney Stein et autres

Abstract Tracking evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within infected individuals will help elucidate coronavirus disease 2019 (COVID-19) pathogenesis and inform use of antiviral interventions. In this study, we developed an approach for sequencing the region encoding the …

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The delayed effect of wildfire season particulate matter on subsequent influenza season in a mountain west region of the USA

Erin L. Landguth, Zachary A. Holden, Jonathan M. Graham, Benjamin Stark et autres

Particularly in rural settings, there has been little research regarding the health impacts of fine particulate matter (PM2.5) during the wildfire season smoke exposure period on respiratory diseases, such as influenza, and their associated outbreaks months later. We examined the delayed effects …

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