Amy M. Norman

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

Is metabolic flexibility determined by early life nutrition

Amy M. Norman

The environment during development has a strong influence on metabolism in later life. In particular, reduced nutrition in early development is associated with obesity in later adulthood. However, the causal mechanisms and processes underlying the phenomenon are not fully defined. The primary …

Postnatal Development of Metabolic Flexibility and Enhanced Oxidative Capacity After Prenatal Undernutrition

Amy M. Norman, Jennifer L. Miles‐Chan, Nichola M. Thompson, Bernhard H. Breier et autres

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Prenatally Induced Changes in Muscle Structure and Metabolic Function Facilitate Exercise-Induced Obesity Prevention

Korinna Huber, Jennifer L. Miles‐Chan, Amy M. Norman, Nichola M. Thompson et autres

Effective regulation of energy metabolism is vital for the maintenance of optimal health, and an inability to make these dynamic adjustments is a recognized cause of obesity and metabolic disorders. Epidemiological and experimental studies have highlighted the role of prenatal factors in …

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P2-20 Prenatal induction of enhanced metabolic flexibility in skeletal muscle

Katrin Huber, Jennifer L. Miles‐Chan, Nichola M. Thompson, Amy M. Norman et autres

Prenatal and Postnatal Pathways to Obesity: Different Underlying Mechanisms, Different Metabolic Outcomes

Nichola M. Thompson, Amy M. Norman, Shawn S. Donkin, Mark H. Vickers et autres

Obesity and type 2 diabetes are worldwide health issues. The present paper investigates prenatal and postnatal pathways to obesity, identifying different metabolic outcomes with different effects on insulin sensitivity and different underlying mechanisms involving key components of insulin receptor signaling pathways. Pregnant …

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