Tapati Basak

Evaluation of Family-Based Ancestry Line Using Pedigree Analysis of Y-Chromosomal Inheritance Pattern – An Application to the Simulated Data

Sumon Matubber, Tapati Basak

Genetic disorders have been a health issue for a long time, and inheritance patterns are a key part of figuring out how diseases are passed down from one generation to the next. While much attention has been given to autosomal and X-linked …

Risk Assessment of X-Chromosomal Recessive Inheritance using Bayesian Approach: A Simulation Study

Sajjad Bin Sogir, Kawser Ahamed, P. Le Roy, Hasibul Hassain Emon et autres

The main objectives of this study were to extract characteristics and to examine the transmission of a trait (disease) through X-linked recessive inheritance patterns in families. The assessment of the risk of inheriting a specific genotype, based on frequentist and Bayesian techniques …

bd (code pays fourni par la source)

Women in Leadership, Skilled Workforce, and Firm Performance in Bangladesh: A Machine Learning Analysis on Enterprise Survey Data

Chandan Kumar Roy, Tapati Basak

This study examines the influence of women’s representation in top management positions and availability of skilled human capital on firm performance in Bangladesh, a critical aspect that remains underexplored in the existing literature. We leverage a fresh and comprehensive dataset of 824 …

bd (code pays fourni par la source)

On the Polymorphism Information Content (PIC) – A Practical Application for the DNA Sequencing Data

P. Le Roy, Sajjad Bin Sogir, Tapati Basak

All traits of an organism are associated with the genes. Organisms carry genes all of their lifetimes and pass them to the next generations. In genetics, case-control linkage studies named Genome-wide association studies (GWAS) are conducted to establish an association between specific …

bd (code pays fourni par la source)

On the Basics of Pedigree Visualization and Feature Extraction for the Autosomal Recessive Inheritance Pattern

Ummay Tania Akter, Sajjad Bin Sogir, Tapati Basak

Pedigree analysis is carried out to understand the mode of inheritance of a particular disease, which includes recessive, dominant, partial dominant, autosomal, mitochondrial or sex-linked etc. It also determines the individual’s probability of affecting in a given cross. Genetic disorders are transmitted …

bd (code pays fourni par la source)

Fundamentals of Pedigree Visualization and Feature Extraction for the Autosomal Dominant Inheritance Pattern

Sajjad Bin Sogir, P. Le Roy, Tapati Basak

The purpose of this study was to examine the transmission of a trait, such as a disease, through an autosomal dominant inheritance pattern under the two distinct situations of full penetrance and reduced penetrance, as well as twins. To assess how a …

bd (code pays fourni par la source)

Genotype-Based Individual Disease Risk for the X-Linked Dominant Ancestry Pattern of Inheritance using Bayesian Approach

P. Le Roy, Tanjum Maheen Zaman, Sajjad Bin Sogir, Moinur Rahman et autres

This study investigates the features of the inheritance patterns of X-linked dominant for different parental genotypic combinations. Risk assessment of an offspring being affected through X-linked dominant inheritance was carried out by calculating genotypic probability by the frequentist (conventional probabilistic) and the …

bd (code pays fourni par la source)

A Preliminary Outline of the Statistical Inference Process in Genetic Association Studies

Tapati Basak, Nipa Roy

The genome-wide association study (GWAS) is a powerful experimental design that is applied to detect disease susceptible genetic variants. The main goal of these studies is to provide a better understanding of the biology of disease, which further facilitates prevention or better …

bd (code pays fourni par la source)

On the Different Ways to Handle the Trend of Disease Risk in Genetic Association Tests

Tapati Basak

Genetic association studies usually apply the simple chi-square (χ2)-test for testing association between a single-nucleotide polymorphism (SNP) and a particular phenotype, assuming the genotypes and phenotypes are independent. So, the conventional χ2-test does not consider the increased risk of an individual carrying …

bd (code pays fourni par la source)

切断正規分布を用いた分割表の幾何学的マルチプルテスティング補正法

Tapati Basak

An Introduction to Basic Statistical Models in Genetics

Tapshir Jahan Setu, Tapati Basak

The use of the three genetic models viz. additive, dominant and recessive in Genome-wide association study (GWAS) is a common and powerful approach to study the association between genetic variants and a trait (disease). The selection of these models depends on the …

bd (code pays fourni par la source)

Interpretation of omics data analyses

Ryo Yamada, Daigo Okada, Juan Wang, Tapati Basak et autres

Omics studies attempt to extract meaningful messages from large-scale and high-dimensional data sets by treating the data sets as a whole. The concept of treating data sets as a whole is important in every step of the data-handling procedures: the pre-processing step …

jp (code pays fourni par la source)