Accès ouvert
2025
article
OpenAlex
Stefan Siewert, Finja Borowski, Swen Großmann, Ariane Dierke et autres
Abstract Proximal Fallopian tube occlusion represents a significant cause of female infertility, limiting natural conception. To address this challenge, we proposed the FemStent previously - a polymer-based, bioresorbable, and self-expanding microstent. To accelerate the epithelialization of the inner stent surface and thus …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jan Oldenburg, Finja Borowski, Laura Supp, Matthias Leuchter et autres
Abstract Minimally invasive transcatheter aortic valve replacement (TAVR) has become the preferred procedure for patients with aortic valve stenosis or insufficiency who are at high risk for conventional open-heart surgery. The favorable clinical outcomes observed in high-risk patients have led to an …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Finja Borowski, Stefan Siewert, Klaus-Peter Schmitz, Michael Stiehm et autres
Abstract Covered stents are increasingly used in the treatment of aortoiliac occlusions and aneurysms. However, the presence of a polymeric cover may inhibit endothelialization and alter blood flow, potentially increasing the risk of thrombosis. Accurate geometric models of the stent lumen are …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Matthias Leuchter, Laura Supp, Jan Oldenburg, Michael Stiehm et autres
Abstract The assesment of the safety and efficacy of medical devices can be time-consuming, expensive, and raise ethical concerns. Additionally, the high costs of innovation and lengthy development times may result in increased prices and unequal access for certain patient groups. In …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Laura Supp, Jan Oldenburg, Christoph Brandt-Wunderlich, Alper Ö Öner et autres
Abstract Transcatheter Aortic Valve Replacement (TAVR) is a widely used treatment for severe aortic stenosis, particularly in patients with a high surgical risk. Although initially designed for tricuspid aortic valves (TAV), its use in bicuspid aortic valves (BAV) presents unique challenges due …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Laura Supp, Jan Oldenburg, Matthias Leuchter, Jan Brüning et autres
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic stenosis, yet paravalvular leakage (PVL) remains a significant complication, associated with increased mortality. Clinical studies have identified correlations between PVL and both anatomical features and calcification patterns. Numerical simulations, particularly …
de, gr, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Laura Supp, Jan Oldenburg, Michelle M. A. Spanjaards, Michael Stiehm et autres
Abstract Due to promising results, the patient cohort for transcather aortic valve replacement (TAVR) has been extended in recent years to include patients with a bicuspid aortic valve (BAV). There are different types of BAV. One variant is the tricommisural bicuspid aortic …
de, nl
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Christopher Lenz, Finja Borowski, Jan Oldenburg, Christoph Brandt-Wunderlich et autres
Abstract Transcatheter aortic valve replacement (TAVR) has become the standard therapy for aortic valve stenosis in patients with high surgical risk. Understanding the flow dynamics in TAVR is crucial for its evaluation and optimization. Experimental flow measurement by means of Particle Image …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Finja Borowski, Laura Supp, Jan Oldenburg, Sebastian Kaule et autres
Abstract Transcatheter aortic valve replacement (TAVR) has become the standard treatment of multimorbid patients with severe aortic valve stenosis. One frequently observed complication after TAVR procedure is the occurence of paravalvular leakage (PVL). PVL is caused by a gap between the vessel …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Jan Oldenburg, Finja Borowski, Laura Supp, Alper Ö Öner et autres
Abstract Minimally invasive transcatheter aortic valve replacement (TAVR) procedure has become the preferred procedure for patients with aortic valve stenosis or insufficiency with high risk for conventional open surgery. The favorable clinical outcomes of high-risk patients led to an expansion of the …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Ariane Dierke, Laura Supp, Finja Borowski, Michael Stiehm et autres
Abstract Involuntary childlessness represents a sensitive and emotionally moving topic. Depending on the method, reproductive treatments are associated with significant physical, psychological and financial burdens. Female sterility is caused by Fallopian tube occlusions in one of three cases. Our previously described microstent …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Michelle M. A. Spanjaards, Finja Borowski, Laura Supp, Valentina Lavezzo et autres
In silico simulations can be used to evaluate and optimize the safety, quality, efficacy and applicability of medical devices. Furthermore, in silico modeling is a powerful tool in therapy planning to optimally tailor treatment for each patient. For this purpose, a workflow …
nl, de
(code pays fourni par la source)