Tae Ho Kim

Itraconazole ameliorates graft-versus-host disease in mice by modulating Th17 responses and STAT3 signaling

Yujin Kim, JooYeon Jhun, Se Gyeong Han, Jeong Won Choi et autres

Background: The resolution of graft-versus-host disease (GVHD) improves survival of patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). T helper 17 (Th17) cells mediate the progression and severity of GVHD. The differentiation of Th17 cells relies on the phosphorylation of signal transducer …

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NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3–IL-17–expressing CD8+ TRM cells

Tae Ho Kim, Chae Rim Lee, Kyoung Min Choi, Soon Won Choi et autres

Abstract Psoriasis is a chronic autoimmune skin disorder characterized by keratinocyte hyperproliferation, persistent inflammation, and frequent relapse. Tissue-resident memory T (TRM) cells, particularly IL-17– and phosphorylated STAT3 (pSTAT3)–expressing CD8 + subsets, have been established as central drivers of disease persistence and recurrence. …

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Additional file 2 of NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3–IL-17–expressing CD8+ TRM cells

Tae Ho Kim, Chae Rim Lee, Kyoung Min Choi, Soon Won Choi et autres

Supplementary Material 2

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Additional file 3 of NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3–IL-17–expressing CD8+ TRM cells

Tae Ho Kim, Chae Rim Lee, Kyoung Min Choi, Soon Won Choi et autres

Supplementary Material 3

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Additional file 3 of NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3–IL-17–expressing CD8+ TRM cells

Tae Ho Kim, Chae Rim Lee, Kyoung Min Choi, Soon Won Choi et autres

Supplementary Material 3

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Additional file 2 of NGO ameliorates psoriasis by modulating mitochondrial function and suppressing pSTAT3–IL-17–expressing CD8+ TRM cells

Tae Ho Kim, Chae Rim Lee, Kyoung Min Choi, Soon Won Choi et autres

Supplementary Material 2

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Vimentin immunization induces TH2/TH17 cell activation and autoantibody production in a novel mouse model of bleomycin induced systemic sclerosis

Chae Rim Lee, Seon-Yeong Lee, Jeonghyeon Moon, Jae-Deog Kim et autres

Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and lung tissues. Currently available drugs delay SSc progression but do not reverse the sclerotic lesions or cure the disease. Studies of its pathogenesis have been hindered …

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Data from Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC

Eun Ji Lee, Seung Yeon Oh, You Won Lee, Ju Young Kim et autres

AbstractPurpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) serve as the standard first-line therapy for EGFR-mutated non-small cell lung cancer (NSCLC). Despite the sustained clinical benefits achieved through optimal EGFR-TKI treatments, including the third-generation EGFR-TKI osimertinib, resistance inevitably develops. Currently, …

Supplementary Figure S2 from Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC

Eun Ji Lee, Seung Yeon Oh, You Won Lee, Ju Young Kim et autres

In vitro activity of BI-4732 against Ba/F3 cells expressing EGFR-activating mutations and T790M mutation

Supplementary Figure S3 from Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC

Eun Ji Lee, Seung Yeon Oh, You Won Lee, Ju Young Kim et autres

In vitro activity of BI-4732 in PDC cells harboring EGFR-activating mutations and T790M mutation

Supplementary Figure S2 from Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC

Eun Ji Lee, Seung Yeon Oh, You Won Lee, Ju Young Kim et autres

In vitro activity of BI-4732 against Ba/F3 cells expressing EGFR-activating mutations and T790M mutation

Supplementary Figure S4 from Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC

Eun Ji Lee, Seung Yeon Oh, You Won Lee, Ju Young Kim et autres

Antitumor efficacy of BI-4732 in PC9-driven intracranial tumor models