Diana Altshuler

Elevated Anti-Xa in the Setting of Prophylactic Unfractionated Subcutaneous Heparin Administration

Tatiana Weinstein, Diana Altshuler, Elyse LaFond, Alyson Katz

Venous thromboembolism prophylaxis with subcutaneous unfractionated heparin or low molecular weight heparin is a common practice in hospitalized patients. Typically, prophylactic doses of these medications have poor bioavailability and thus do not reach therapeutic serum concentrations. However, in certain circumstances, heparin binding …

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Low dose vs high dose tocilizumab in COVID-19 patients with hypoxemic respiratory failure

Juri Chung, Shari B. Brosnahan, Shahidul Islam, Diana Altshuler et autres

PURPOSE: Tocilizumab has been shown to decrease mortality when used concomitantly with steroids in COVID-19 with 8 mg/kg (max 800 mg) being the standard dose. Our study sought to assess whether a low dose (400 mg) shows similar benefit compared to a …

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1108: LOW-DOSE VERSUS HIGH-DOSE TOCILIZUMAB IN COVID-19 PATIENTS WITH HYPOXIC RESPIRATORY FAILURE

Wai Man Wang, Xian Jie Chen, Juri Chung, Wai Kin Li et autres

Introduction: Tocilizumab has been shown to decrease mortality when used concomitantly with steroids in COVID-19. Tocilizumab dose of 8 mg/kg (max: 800 mg), stemmed from the RECOVERY trial, has been the standard dose for COVID. Due to a drug shortage of tocilizumab, …

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804: SUGAMMADEX (BRIDION) MEDICATION USE EVALUATION IN A 591-BED TEACHING HOSPITAL

Matt Niewinski, Shan Wang, Diana Altshuler

Introduction: Sugammadex is a modified gamma cyclodextrin encapsulating agent that reverses the action of neuromuscular blocking agents [NMBA] rocuronium and vecuronium. It is one of our institutional’ s high cost medications. As compared to neostigmine, sugammadex has lower incidence of bradycardia, post-operative …

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308: MEDICATION USE EVALUATION OF ALVIMOPAN IN A TEACHING HOSPITAL

Wai Man Wang, Shan Wang, Diana Altshuler

Introduction: Post-Operative ileus (POI) is one of the most expected complications of major abdominal surgery. It is the most common cause of delayed hospital discharge. POI results from inflammatory reaction and effects of opioids analgesics. Alvimopan is an opioid antagonist, designed to …

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481: INTRAVENOUS IMMUNOGLOBULIN (IVIG) FOR SEVERE OR FULMINANT CLOSTRIDIUM DIFFICILE INFECTION

Olivia Nuti, Diana Altshuler, Serena Arnouk, Alyson Katz et autres

Introduction: Clostridium difficile infection (CDI) is associated with significant morbidity and mortality. Salvage therapy may include IVIG, fecal microbiota transplant (FMT) or colectomy. There is limited data regarding the effectiveness of IVIG for CDI (43-65%) or optimal dosing strategies. Methods: This is …

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Efficacy and safety of propofol dosing based on ideal body weight vs. actual body weight: a retrospective cohort study

Ilana Gimelbrand, Cristian Merchan, Prachi Bhatt, Chanie Wassner et autres

Background: Various weight-based strategies using actual, ideal, adjusted, and lean body weights (LBWs) have been studied for propofol dosing finding that propofol is better related to LBW as opposed to actual body weight (ABW). However, the most common dosing strategy is based …

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The incidence of propofol infusion syndrome in critically-ill patients

Wai Kin Li, Xian Jie Cindy Chen, Diana Altshuler, Shahidul Islam et autres

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Outcomes of Cytomegalovirus Viremia Treatment in Critically Ill Patients With COVID-19 Infection

Scott Schoninger, Yanina Dubrovskaya, Kassandra L Marsh, Diana Altshuler et autres

Abstract Background Patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU) have poor outcomes and frequently develop comorbid conditions, including cytomegalovirus (CMV) reactivation. The implications of CMV reactivation in this setting are unknown. We aimed to investigate if …

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The Use of High-Dose Corticosteroids Versus Low-Dose Corticosteroids With and Without Tocilizumab in COVID-19 Acute Respiratory Distress Syndrome

Alyson Katz, Diana Altshuler, John Papadopoulos, Nancy E. Amoroso et autres

Background: Corticosteroids and tocilizumab have been shown to improve survival in patients who require supplemental oxygen from coronavirus disease 2019 (COVID-19) pneumonia. The optimal dose of immunosuppression for the treatment of COVID-19 acute respiratory distress syndrome (ARDS) is still unknown. Objective: The …

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Antithrombotic management for Impella ® temporary ventricular assist devices: An analysis of an academic health-system experience

Olivia Iskaros, Tania Ahuja, Serena Arnouk, Bridget Toy et autres

The use of acute mechanical circulatory support (MCS) has increased over the last decade. For patients with left-ventricular failure, an Impella ® (Abiomed, Danvers, MA) may be used to improve cardiac output. The purpose of this study is to describe Impella ® …

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925: PREVALENCE OF PROPOFOL INFUSION SYNDROME IN CRITICALLY ILL PATIENTS

Wai Kin Li, Xian Jie Chen, Diana Altshuler, Shahidul Islam et autres

Li, Wai Kin1; Chen, Xian Jie2; Altshuler, Diana3; Islam, Shahidul4; Emerson, Liane5; Spiegler, Peter2; Bender, Michael6 Author Information

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