Ariel A. Hippen

Intravitreal AAV vector delivery induces integrin-dependent ocular inflammation, complement activation, and antiviral and DNA damage responses

Helena Costa Verdera, Deepa R. Jamwal, Emily Fabyanic, Ariel A. Hippen et autres

Background Intravitreal delivery of adeno-associated virus (AAV) vectors offers a promising, minimally invasive strategy for retinal gene therapy, but remains limited by dose-dependent intraocular inflammation. Corticosteroid therapy, the current standard for managing gene therapy-associated uveitis (GTAU), can be ineffective or contraindicated, highlighting …

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Administration of a barcoded AAV capsid library to the putamen of non-human primates identifies variants with efficient retrograde transport

Yulia Dzhashiashvili, Jodi L. McBride, Emily Fabyanic, Xin Huang et autres

Adeno-associated viral vectors have become a leading choice for gene therapy in the central nervous system due to their safety profile, efficient neuronal transduction, and capacity for sustained transgene expression. We previously reported that AAV2-derived capsids developed using the BRAVE (Barcoded Rational …

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Administration of barcoded AAV capsid library to the putamen of non-human primates identifies variants with efficient retrograde transport

Yulia Dzhashiashvili, Jodi L. McBride, Emily Fabyanic, Xin Huang et autres

ABSTRACT Adeno-associated viral vectors have become a leading choice for gene therapy in the central nervous system due to their safety profile, efficient neuronal transduction, and capacity for sustained transgene expression. We previously reported that AAV2-derived capsids developed using the BRAVE (Barcoded …

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Supplementary Table S4 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

SchildkrautW derived expression data

Supplementary Table S5 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

SchildkrautB metadata

Supplementary Figure S9 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

SchildkrautB subtype labeling comparisons

Supplementary Figure S14 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

KM survival curves by study population

Supplementary Figure S11 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

SAM moderated t score correlation heatmaps by dataset for k3

Supplementary Figure S4 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

Evaluation of sample quality in Schildkraut datasets

Supplementary Figure S16 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

KM survival curves comparing consensusOV subtype specific survival by dataset

Supplementary Figure S2 from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

Case selection for self-identified White study participants

Data from Molecular Subtypes of High-Grade Serous Ovarian Cancer across Racial Groups and Gene Expression Platforms

Natalie R. Davidson, Mollie E. Barnard, Ariel A. Hippen, Amy Campbell et autres

AbstractBackground: High-grade serous carcinoma (HGSC) gene expression subtypes are associated with differential survival. We characterized HGSC gene expression in Black individuals and considered whether gene expression differences by self-identified race may contribute to poorer HGSC survival among Black versus White individuals. Methods: …