Ai‐Xia Cheng

Functional identification of key enzymes in calycosin biosynthesis in Astragalus membranaceus and establishment of heterologous expression system

Ming-Xin Cui, Yue Hao, Jiang-Nan Li, Dan-Dan Xu et autres

Astragalus membranaceus , a widely used medicinal and edible herb, contains major active isoflavonoid components such as formononetin, calycosin, and their glycosides, which exhibit a broad spectrum of pharmacological effects including anti-inflammatory, immunomodulatory, and cardioprotective activities. In this study, we identified three …

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Divergent synthesis of Haplomitrium diterpenoids via a late-stage biomimetic skeletal reorganization approach

Cheng‐Yong Su, Haixia Zhang, Yueqing Zhang, Xiaoxue Chen et autres

Labdane-type terpenoids, the large super-family of diterpenoids, exhibit diverse biological significance. Labdane-derived hapmnioide-type diterpenoids, which have been identified as chemical markers for Haplomitrium liverwort, show potent anti-inflammatory and allelopathic activities. Biosynthetically, their structural complexity and diverse carbon skeletons arise from cascade ring …

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Divergent synthesis of Haplomitrium diterpenoids via a late-stage biomimetic skeletal reorganization approach

Hong‐Xiang Lou, Cheng‐Yong Su, Haixia Zhang, Yueqing Zhang et autres

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Haploides A–G: Diterpenoids featuring four new carbon skeletons via non-carbocation-driven skeletal diversification

Ming‐Zhu Zhu, Zejun Xu, Jiao‐Zhen Zhang, Yi Li et autres

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Functional characterization of key enzymes involved in the biosynthesis of distinctive flavonoids and stilbenoids in Morus notabilis

Mengwen Hu, Jie Fu, Ying Lu, Xinyan Liu et autres

Abstract The mulberry (Morus notabilis) is a medicinal and edible plant and contains diverse flavonoids and stilbenoids with significant medicinal benefits. The biosynthesis of these compounds has only been partially elucidated. In the present investigation, we identified and characterized two 4-coumarate: coenzyme …

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Functional characterization of promiscuous 2‐ ODD enzymes sheds light on the molecular basis for flavone and flavonol biosynthesis in ferns

Jie Fu, Ying Lu, Junli Zhang, Rong Ni et autres

Flavone synthase I (FNS I), flavanone 3-hydroxylase (F3H), and flavonol synthase (FLS) are essential enzymes involved in the biosynthesis of flavones and flavonols. Notably, while FNS I and F3H have been extensively studied in early land plants, FLS has predominantly been characterized …

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Unraveling the hydroxylation and methylation mechanism in polymethoxylated flavones biosynthesis in Dracocephalum moldavica

Hui Yin Tan, Jie Fu, Jiao‐Zhen Zhang, Tingting Zhu et autres

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Systematic molecular dissection of key intermediates in xanthones biosynthesis in Cudrania tricuspidata and establishment of a viable heterologous expression system

Jing Zhang, Dandan Xu, Tingting Zhu, He Ta et autres

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Characterization and functional analysis of type III polyketide synthases in Selaginella moellendorffii

Xinyan Liu, Shuai Gao, Ai‐Xia Cheng, Hong‐Xiang Lou

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Reversible Glc‐conjugation/hydrolysis modulates the homeostasis of lunularic acid in Marchantia polymorpha growth

Tingting Zhu, Yuliang Xu, He Ta, Jiao‐Zhen Zhang et autres

The circadian clock efficiently coordinates growth regulators and plant growth in the temporal regulation of physiological processes. The involvement of the growth-regulator-clock in governing the spatio-temporal regulation of plant growth and development remains unexplained in the nonvascular liverworts. In this study, we …

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Catalytic divergence of O‐methyltransferases shapes the chemo‐diversity of polymethoxylated bibenzyls in Dendrobium catenatum

He Ta, Yahui Yang, Tingting Zhu, Ni‐Hong Du et autres

Erianin, crepidatin, and chrysotobibenzyl are typical medicinal polymethoxylated bibenzyls (PMBs) that are commercially produced in Dendrobium species. PMBs' chemo-diversity is mediated by the manifold combinations of O-methylation and hydroxylation in a definite order, which remains unsolved. To unequivocally elucidate the methylation mechanism …

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Shuttle Peptide Achieves Intracellular Airway Delivery of Phosphorodiamidate Morpholino Oligonucleotide (PMO) in Mucus Hypersecretion Lung Environment

Ai‐Xia Cheng, Maxime Hervault, Mia Pelletier, Anne-Marie Duperré et autres

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