Martina Schaettin

Adapting in ovo RNAi as a tool to study gene function during neural circuit formation in the cerebellum

Aikaterini Koutourlou, Martina Schaettin, Esther T. Stoeckli

BACKGROUND: The cerebellum is not only essential for motor control but also involved in higher cognitive functions and emotion processing. Its involvement in neurodevelopmental disorders, such as autism spectrum disorders and attention deficit hyperactivity disorder, has enhanced interest in molecular and cellular …

ch (code pays fourni par la source)

Very long-chain fatty acids drive 1-deoxySphingolipid toxicity

Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin et autres

1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids formed when serine palmitoyltransferase incorporates L-alanine instead of L-serine. Elevated 1-deoxySLs are associated with hereditary sensory neuropathy type 1 and diabetic neuropathy, but the molecular basis of their toxicity remains unclear. Here we show that toxicity is …

ch, us, fr, jp (code pays fourni par la source)

Very long-chain fatty acids drive 1-deoxySphingolipid toxicity

Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin et autres

1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids formed when serine palmitoyltransferase incorporates L-alanine instead of L-serine. Elevated 1-deoxySLs are associated with hereditary sensory neuropathy type 1 and diabetic neuropathy, but the molecular basis of their toxicity remains unclear. Here we show that toxicity is …

Very long-chain fatty acids drive 1-deoxySphingolipid toxicity

Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin et autres

1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids formed when serine palmitoyltransferase incorporates L-alanine instead of L-serine. Elevated 1-deoxySLs are associated with hereditary sensory neuropathy type 1 and diabetic neuropathy, but the molecular basis of their toxicity remains unclear. Here we show that toxicity is …

Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity

Adam Majcher, Gergely Karsai, Elkhan Yusifov, Martina Schaettin et autres

Abstract 1-deoxy-sphingolipids (1-deoxySLs) are atypical sphingolipids synthesized by the serine palmitoyltransferase (SPT) when L-alanine is used instead of its canonical substrate L-serine. Increased 1-deoxySLs are associated with sensory neuropathies such as Hereditary Sensory and Autonomic Neuropathy type 1 (HSAN1) and diabetic polyneuropathy …

ch, us, fr (code pays fourni par la source)

The primary cilium gene CPLANE1 is required for peripheral nervous system development

Elkhan Yusifov, Martina Schaettin, Alexandre Dumoulin, Ruxandra Bachmann‐Gagescu et autres

Ciliopathies are a group of neurodevelopmental disorders characterized by the dysfunction of the primary cilium. This small protrusion from most cells of our body serves as a signaling hub for cell-to-cell communication during development. Cell proliferation, differentiation, migration, and neural circuit formation …

ch (code pays fourni par la source)

2-Methoxyestradiol, an Endogenous 17β-Estradiol Metabolite, Induces Antimitogenic and Apoptotic Actions in Oligodendroglial Precursor Cells and Triggers Endoreduplication via the p53 Pathway

Sara Schaufelberger, Martina Schaettin, Giovanna Azzarito, Marinella Rosselli et autres

The abnormal growth of oligodendrocyte precursor cells (OPCs) significantly contributes to the progression of glioblastoma tumors. Hence, molecules that block OPC growth may be of therapeutic importance in treating gliomas. 2-Methoxyestradiol (2ME), an endogenous tubulin-interacting metabolite of estradiol, is effective against multiple …

ch (code pays fourni par la source)

2-Methoxyestradiol, an Endogenous 17β-Estradiol Metabolite, Induces Antimitogenic and Apoptotic Actions in Oli-Neu – Oligodendroglial Precursor Cells and Triggers Endoreduplication via p53 Pathway

Sara Schaufelberger, Martina Schaettin, Giovanna Azzarito, Marinella Rosselli et autres

Abstract: Abnormal growth of oligodendrocyte precursor cells (OPCs) importantly contributes to the progression of glioblastoma tumors. Hence, molecules that block OPC growth may be of therapeutic importance in treating gliomas. 2-methoxyestradiol (2ME), an endogenous tubulin interacting metabolite of estradiol is effective against …

ch (code pays fourni par la source)

Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples

Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, G. R. Araujo et autres

In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of such …

ch, us, de, nl (code pays fourni par la source)

The Primary Cilium Gene Cplane1 is Required for Peripheral Nervous System Development

Elkhan Yusifov, Martina Schaettin, Alexandre Dumoulin, Esther T. Stoeckli et autres

The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples

Nikita Vladimirov, Fabian F. Voigt, Thomas Naert, G. R. Araujo et autres

In 2015, we launched the mesoSPIM initiative (www.mesospim.org), an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of …

ch, us, de, nl (code pays fourni par la source)

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Fabian F. Voigt, Anna Maria Reuss, Thomas Naert, Sven Hildebrand et autres

Imaging large, cleared samples requires microscope objectives that combine a large field of view (FOV) with a long working distance (WD) and a high numerical aperture (NA). Ideally, such objectives should be compatible with a wide range of immersion media, which is …

us, ch, nl, au, de (code pays fourni par la source)