Federico De Marchi

Putting the I in AML: Artificial Intelligence and Machine Learning in Acute Myeloid Leukemia

Federico De Marchi, Giulia Ciotti, Alessandro Atanasio, Giovanni Pascarella et autres

Artificial intelligence (AI) and machine learning (ML) now reach into every stage of AML care. Deep learning models read therapy-relevant mutations directly from bone marrow smears; automated flow cytometry gating reproduces expert calls in under a minute; and the first AI pathology …

The Role of the Bone Marrow Microenvironment in the Pathogenesis of Acute Myeloid Leukemia

Michele Gottardi, Federico De Marchi, Giulia Ciotti, Marco Basso et autres

Acute myeloid leukemia (AML) develops within a bone marrow environment that influences leukemic stem cell behavior, residual disease, and response to therapy. This review examines evidence that the marrow microenvironment is not only a site of leukemic growth, but can actively shape …

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The Role of the Bone Marrow Microenvironment in the Pathogenesis of Acute Myeloid Leukemia

Michele Gottardi, Federico De Marchi, Giulia Ciotti, Marco Basso et autres

Acute myeloid leukemia (AML) develops within a bone marrow environment that influences leukemic stem-cell behavior, residual disease, and response to therapy. This review examines evidence that the marrow microenvironment is not only a site of leukemic growth, but can actively shape AML …

ACSL4-driven ferroptosis susceptibility as a targetable vulnerability in monocytic acute myeloid leukemia

Federico De Marchi, Michele Gottardi

Ferroptosis, an iron-dependent form of regulated cell death driven by lethal lipid peroxidation, has emerged as a targetable vulnerability in cancer. ACSL4 is the rate-limiting enzyme that dictates ferroptosis sensitivity by channeling polyunsaturated fatty acids into membrane phospholipids. In acute myeloid leukemia …

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Salvage use of tacrolimus in steroid-refractory severe immune hepatitis from vulvar melanoma immunotherapy

Luca Marzi, Federico De Marchi, Francesco Erdini, C Turri et autres

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Involvement of CREB3L1 in erythropoiesis induced by JAK2 exon 12 mutation

Maho Okuda, Marito Araki, Federico De Marchi, Soji Morishita et autres

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Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms

Federico De Marchi, Maho Okuda, Soji Morishita, Misa Imai et autres

Cyclic AMP-response element-binding protein 3-like 1 (CREB3L1) is a gene involved in the unfolded protein response (UPR). Recently, we demonstrated that CREB3L1 is specifically overexpressed in the platelets of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). In this study, we aimed to …

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OC.04.4 SUPERVISED MACHINE LEARNING TECHNIQUES FOR THE PREDICTION OF HEPATOCELLULAR CARCINOMA (HCC) RELAPSE

Andrea Mega, A. Andreotti, Fabio Vittadello, Luca Marzi et autres

Whole‐exome sequencing identifies functional classes of gene mutations associated with bone marrow failure in pediatric Fanconi Anemia patients

Shiyu Wang, Natalia Zbib, Alyza Skaist, Jiang Gui et autres

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Clonal Origin Evaluated by Trunk and Branching Drivers and Prevalence of Mutations in Multiple Lung Tumor Nodules

Erika F. Rodriguez, Li‐Hui Tseng, Federico De Marchi, Jialing Haung et autres

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IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution

Erika F. Rodriguez, Federico De Marchi, Parvez M. Lokhandwala, Deborah Belchis et autres

BACKGROUND: Selective IDH1 and IDH2 inhibitors have been approved for targeted therapy of acute myeloid leukemia. Clinical trials for solid tumors with IDH1 and IDH2 (IDH1/2) mutations are ongoing. Reports of IDH1/2-mutated non-small cell lung cancers (NSCLCs), however, are limited. METHODS: We …

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The diagnostic utility of targeted gene panel sequencing in discriminating etiologies of cytopenia

Gang Zheng, Ping Chen, Aparna Pallavajjalla, Lisa Haley et autres

The diagnostic utility of somatic mutations in the context of cytopenias is unclear: clonal hematopoiesis can be found in healthy individuals, patients with aplastic anemia (AA), clonal cytopenia of undetermined significance (CCUS) and myelodysplastic syndrome (MDS). We examined a cohort of 207 …

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