Yu Peng

Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in multiple myeloma

Li Xu, Hui Zhang, Kai Wang, Xuejie Gao et autres

• The survival rates between six copper death-related genens (CRGs) and multiple myeloma (MM) were significantly correlated. • Cuproptosis molecular subtypes in MM patients exhibited significant associations with clinical features, prognosis, and immune cell infiltration. • Five key biomarkers displayed distinct immune …

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PTGFRN promotes non-small cell lung cancer malignant progression and reprograms BCAA metabolism by activating STAT3/BCAT1 pathway

Feiye Liu, Mengjie Li, Yu Peng, Chuanchun Han et autres

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Overcoming antigen tolerance to develop GB22–45-2, an anti-DKK1 antibody for gastric cancer

Wenjun Zhang, Xiling Wei, Bo Liang, Xiaodong Yang et autres

Abstract Background Gastric cancer (GC) represents one of the most prevalent and lethal malignancies, however, current treatments have shown limited efficacy. Clinical investigations have revealed that Dickkopf-1 (DKK1)-high GC patients are associated with poor prognosis, and DKK1 expression is negatively correlated with …

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Structured In-context Environment Scaling for Large Language Model Reasoning

Yu Peng, Zeyuan Zhao, Zhang Shao, Luoyi Fu et autres

Large language models (LLMs) have achieved significant advancements in reasoning capabilities through reinforcement learning (RL) via environmental exploration. As the intrinsic properties of the environment determine the abilities that LLMs can learn, the environment plays a important role in the RL finetuning …

1194P Efficacy and safety of sintilimab in combination with weekly paclitaxel and anlotinib in patients with platinum-resistant recurrent epithelial ovarian cancer: Results from the interim analysis of the phase II single-arm study

Zhihong Liu, Xiaomei S. Cong, Chen Chen, Ruhui Li et autres

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Nutritional and immune-inflammatory scoring system for predicting outcomes in newly diagnosed diffuse large B-cell lymphoma patients

Yu Peng, Tingting Jiang, Shuang Chen, Xinyi Tang et autres

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma and often carries a poor prognosis. Current prognostic systems such as the International Prognostic Index (IPI) and National Comprehensive Cancer Network (NCCN)-IPI do not incorporate patients' nutritional, immune, or …

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Prostate cancer exploits BRD9-driven metabolic reprogramming to shape the aggressive phenotype

Ye Lv, Xinkai Mo, Ruojia Zhang, Yu Peng et autres

The aggressive phenotype of prostate cancer (PCa) requires adaptation to androgen deprivation (AD) to progress into castration-resistant PCa (CRPC), including adaptation to AD-induced oxidative stress. However, our understanding of the oncogenes that maintain the redox balance during CRPC progression is limited. Here, …

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Analysis of Multiple Programmed Cell Death Patterns and Functional Validations of Apoptosis-Associated Genes in Lung Adenocarcinoma

Yu Peng, Nan Jia, Jingyu Wang, Shilei Dong et autres

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176TiP: Perioperative adebrelimab plus chemotherapy for resectable non-small cell lung cancer harboring EGFR mutations: A multicenter, phase II trial

Guomin Wang, Jiaqi Li, Yuanhua Liu, Jianhua Xie et autres

Causal Associations Between Liver Function Biomarkers and Prostate Cancer Risk in European and East Asian Populations: A Univariate, Multivariate, and Bidirectional Mendelian Randomization Study

Xinyu Xu, Wenjing Zhu, Yu Peng

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A Synergistically Enhanced Triboelectric‐Electromagnetic Hybrid Generator Enabled by Multifunctional Amorphous Alloy for Highly Efficient Self‐Powered System

Shaokun Gong, B.Z. Tang, Chengxu Liu, Wei Hong Zhao et autres

Abstract Triboelectric‐electromagnetic hybrid generator (TEHG) has emerged as an effective technology for mechanical energy harvesting. However, the independent operation of triboelectric nanogenerator (TENG) and electromagnetic generator (EMG), along with tribo‐materials wear and magnetic field divergence, constrain the device's overall performance. To address …

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Identifying a cis-element in PtoCP1 promoter for efficiently controlling constitutive gene expression in Populus tomentosa

Yu Peng, Xueqin Guo, Yawei Fan, Han Liu et autres

Gene expression is regulated by transcription factors binding to cis-elements in promoters. However, efficient cis-elements for genetic engineering are rarely reported. In this study, we identified an 11 bp cis-element in the PtoCP1 promoter that drives strong constitutive gene expression in Populus …

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