Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee et autres
2 citationsCell Reports
Bradley Class
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17Publications signalées
240Citations signalées
1Affiliations récentes
Institutions déclarées
Domaines associés
Inflammatory Myopathies and DermatomyositisProtein Degradation and InhibitorsMuscle Physiology and DisordersMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways
Publications récentes
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee et autres
18 citationsCell Reports
Abstract CT186: Pharmacokinetic (PK) profile of a novel IKZF1/3 degrader, CFT7455, enables significant potency advantage over other IKZF1/3 degraders in models of multiple myeloma (MM) and the results of the initial treatment cohort from a first-in-human (FIH) phase 1/2 study of CFT7455 in MM
Sagar Lonial, Shambavi Richard, Jeffrey Matous, Andrew J. Yee et autres
11 citationsCancer Research
Abstract ND13: The discovery and characterization of CFT7455: A potent and selective degrader of IKZF1/3 for the treatment of relapsed/refractory multiple myeloma
James A. Henderson, Scott J. Eron, Andrew C. Good, Ruth Kirby et autres
4 citationsCancer Research
Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy
Mari Aikio, Heike J. Wobst, Hana M. Odeh, Bo Lim Lee et autres
10 citationsbioRxiv (Cold Spring Harbor Laboratory)
Safety and efficacy of N-acetylmannosamine (ManNAc) in patients with GNE myopathy: an open-label phase 2 study
Nuria Carrillo, May Christine V. Malicdan, Petcharat Leoyklang, Joseph A. Shrader et autres
58 citationsGenetics in Medicine
Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models
James A. Henderson, R. Jason Kirby, Samantha Perino, Roman V. Agafonov et autres
8 citationsCancer Research
CFT7455: A NOVEL, IKZF1/3 DEGRADER THAT DEMONSTRATES POTENT TUMOR REGRESSION IN A SPECTRUM OF NHL XENOGRAFT MODELS
S. Perino, Bradley Class, Christina S. Henderson, Marta Isasa et autres
5 citationsHematological Oncology
Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts
Kirill Gorshkov, Amy Q. Wang, Wei Sun, Ethan G. Fisher et autres
8 citationsPharmacology Research & Perspectives
Quantitation of cytidine‐5′‐monophospho‐N‐acetylneuraminic acid in human leukocytes using LC–MS/MS: method development and validation
Meng Fang, Xin Xu, Michael Zhang, Yifan Shi et autres
8 citationsBiomedical Chromatography
Open-Label Phase 2 Clinical Trial of ManNAc for GNE Myopathy (S23.008)
Nuria Carrillo, Marjan Huizing, Petcharat Leoyklang, Melanie Quintana et autres
2 citationsNeurology
Quantification of lectin fluorescence in GNE myopathy muscle biopsies
Petcharat Leoyklang, Bradley Class, S. Noguchi, William A. Gahl et autres
19 citationsMuscle & Nerve
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