Susana M. M. Lopes

Targeting endometrial cancer stem cells through aldehyde dehydrogenase-mediated photodynamic therapy based on enhanced ring-fused chlorins

Beatriz Serambeque, Bruna Costa, Soraia Ferreira, Sofia Pinto Lopes et autres

endometrial CSC.

pt (code pays fourni par la source)

Knowledge Updates 2026/1

J. M. Campagne, J. J. Li, M. Oestreich, S. Z. Zard et autres

41.2.3 Nitrosoalkanes and Nitroso Acetals (N,N-Dialkoxyamines) (Update 2026)

Maria I. L. Soares, Susana M. M. Lopes, Ana Lúcia Cardoso, Marta Piñeiro et autres

Abstract Nitrosoalkanes and nitroso acetals (N,N-dialkoxyamines) have emerged as highly versatile intermediates in modern organic synthesis, despite their intrinsic instability and tendency toward tautomerization and dimerization. This review provides an updated and comprehensive overview of their synthesis, reactivity, and applications. Recent advances …

Structural modifications of abietic acid and a computational protocol to predict their compatibility in different environments

J. N. A. Macêdo, Pedro Miranda, Américo J. S. Alves, Cláudia Alves et autres

values, showing good agreement between computed and experimental trends. The calculations correctly capture subtle conformational effects, including the pseudo-amphiphilic character of dodecyl abietate arising from folded conformations. Overall, the computational framework provides a predictive tool for guiding the rational design of abietic …

pt (code pays fourni par la source)

from synthesis and property evaluation to applications in light-emitting diodes

Ana C. Amorim, Jorge Morgado, João P. Prates Ramalho, Hugo Cruz et autres

Despite its promising electronic and semiconducting properties, 12H-phthaloperin-12-one remains a largely unexplored molecule, with limited studies regarding the impact of structural modifications on its properties and its application in light-emitting devices. To address this gap, we report the synthesis of 12 novel …

pt (code pays fourni par la source)

Synthetic Pathway to trans -A 2 B 2 -Porphyrins: From Oxime-Substituted Dipyrromethanes to Functionalized Macrocycles

João C. S. Simões, Bruna D. P. Costa, Ana Clara B. Rodrigues, Susana M. M. Lopes et autres

An unprecedented approach to trans -A 2 B 2 -porphyrins from α-oxime-functionalized dipyrromethanes has been disclosed. Initially aimed at BODIPY synthesis, the process serendipitously yielded porphyrins with photophysical properties suitable for use as photosensitizers in photodynamic therapy (PDT), as mirrored by its …

pt (code pays fourni par la source)

trans-A2B-Corroles containing an oxime moiety: Novel photosensitizers for photodynamic therapy of lung cancer

João Braz, Catarina Mestre, Susana M. M. Lopes, Ana Clara B. Rodrigues et autres

A series of fourteen trans -A 2 B-corroles containing an oxime moiety were synthesized based on the reactivity of nitrosoalkenes towards dipyrromethanes, to evaluate their potential as a safe therapeutic option for photodynamic therapy (PDT) of lung cancer (LC). These macrocycles exhibited …

pt (code pays fourni par la source)

Bilateral skull asymmetries in two ancient semi-feral horse breeds and their implications for archaeological equine studies:

Pere Miquel Parés-Casanova, Nuno Pimentel Carolino, José V. Leite, Susana M. M. Lopes et autres

Hydrazone-Functionalized trans -A 2 B-Corroles: Effective Synergy in Photodynamic Therapy of Lung Cancer

Bruna D. P. Costa, João C. S. Simões, Susana M. M. Lopes, Mafalda Laranjo et autres

A synthetic route to trans -A 2 B-corroles combining the macrocyclic core with a hydrazone moiety, based on the reactivity of azoalkenes toward dipyrromethanes, has been established with the aim of developing a new class of photosensitizers for photodynamic therapy of lung …

pt, it, hu, bg (code pays fourni par la source)

3-Tetrazolyl-β-carboline derivatives as potential neuroprotective agents

João Ribeiro, Inês Costa, Renata Silva, Susana M. M. Lopes et autres

3-Tetrazolyl-β-carbolines were prepared by the Pictet-Spengler approach using a tryptophan analogue as building block, in which the carboxylic acid was replaced by the bioisosteric tetrazole group. Knowing that β-carbolines are often associated with psychopharmacological effects, the study of the 3-tetrazolyl-β-carbolines as potential …

pt (code pays fourni par la source)

CCDC 2174469: Experimental Crystal Structure Determination

Bernardo Albuquerque Nogueira, Susana M. M. Lopes, Ana Clara B. Rodrigues, M. Ermelinda S. Eusébio et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2177884: Experimental Crystal Structure Determination

Bernardo Albuquerque Nogueira, Susana M. M. Lopes, Ana Clara B. Rodrigues, M. Ermelinda S. Eusébio et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …