Matthias Schefzyk

D18-09 The Multiorgan Multicenter Spatial Transcriptomics Atlas Reveals Layered Granuloma Architecture and Cellular Programs Driving Sarcoidosis

Jannik Ruwisch, Leonard Christian, Stephan Traidl, J Dietrich et autres

Abstract Rationale Sarcoidosis is an inflammatory disease of unknown cause characterized by granulomatous immune cell aggregates across multiple organs. While granulomas exhibit a broadly conserved histological architecture, a spatially resolved understanding of their cellular organization and organ-specific features remains incomplete. Here, we …

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A phase 2b basket trial approach to treat multiple rare and fibrotic skin diseases

Sebastian Volc, Peter Martus, Matthias Schefzyk, Claudia Günther et autres

Fibrotic skin diseases are rare, chronic, and often debilitating conditions characterized by excessive extracellular matrix deposition, leading to tissue scarring and functional impairment. Despite their severity, diseases-such as lichen sclerosus et atrophicus (LSA), frontal fibrosing alopecia (FFA), radiation-induced skin fibrosis (RISF), eosinophilic …

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Interleukin-4 and -13 Gene Expression Profiles in Immune-Related Bullous Pemphigoid Indicate Efficacy of IL-4/IL-13 Inhibitors

Lisa Arnold, Monika Morak, Nora Kramer, Carola Berking et autres

Background/Objectives: Cutaneous side effects are the most common immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) and affect 70–90% of patients. Besides diverse types of exanthema, rare skin toxicity includes bullous dermatoses in 0.3% of cases. Systemic steroids are the …

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Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders

Franz Felix Konen, Nora Möhn, Torsten Witte, Matthias Schefzyk et autres

A wide variety of immunomodulatory therapies are already available for the treatment of multiple sclerosis (MS). Through fundamental insights from basic research with a gain of knowledge in the pathological processes underlying MS, the exploration of additional medical compounds within clinical trials …

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Toll‐Like Receptor 8 is Expressed in Monocytes in Contrast to Plasmacytoid Dendritic Cells and Mediates Aberrant Interleukin‐10 Responses in Patients With Systemic Sclerosis

Christine Ehlers, Thea Thiele, Hannah Biermann, Stephan Traidl et autres

OBJECTIVE: Systemic sclerosis (SSc) is a severe rheumatic disease causing fibrotic tissue rearrangement. Aberrant toll-like receptor (TLR) 8 transcripts in plasmacytoid dendritic cells (pDCs) were recently linked to SSc pathogenesis, which is at least partially mediated by increased type I interferon (IFN-I) …

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Checkpoint inhibitor‐induced bullous pemphigoid differs from spontaneous bullous pemphigoid

Nora Kramer, Gunnar Müller, Sarah Zierold, Magdalena Röckel et autres

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Impact of COVID ‐19 in patients with autoimmune bullous diseases: Report from an international registry

Joost M. R. Meijer, Hanan Rashid, Styliani Vergadi, Emiliano Antiga et autres

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Treatment of autoimmunity: The impact of disease-modifying therapies in multiple sclerosis and comorbid autoimmune disorders

Franz Felix Konen, Nora Möhn, Torsten Witte, Matthias Schefzyk et autres

More than 10 disease-modifying therapies (DMT) are approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for the treatment of multiple sclerosis (MS) and new therapeutic options are on the horizon. Due to different underlying therapeutic …

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Kutane thrombotische Mikroangiopathie bei gemischter Kryoglobulinämie bei einer jungen Frau

Stephan Traidl, Jan Hinrich Bräsen, Matthias Schefzyk

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Cutaneous thrombotic microangiopathy due to mixed cryoglobulinemia in a young woman

Stephan Traidl, Jan Hinrich Bräsen, Matthias Schefzyk

Cutaneous thrombotic microangiopathy due to mixed cryoglobulinemia in a young woman Dear Editors, a 23-year-old woman presented to the dermatology clinic with a two-week history of painful skin lesions.The lesions appeared without an identifiable cause on cheeks and the upper left arm.The …

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Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Muhammad Nasir Hayat Malik, Syed Fakhar‐ul‐Hassnain Waqas, Jana Zeitvogel, Jingyuan Cheng et autres

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous …

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Hemorrhagic rash on the legs

Stephan Traidl, Yenny Angela, Alexander Kapp, Matthias Schefzyk

A 42-year-old woman presented with hemorrhagic macules and papules, especially affecting the lower extremity (Fig 1). Two weeks prior to presentation, she had cough, diarrhea, malaise, and limb pain. Infection with COVID-19 was confirmed through polymerase chain reaction. The rash began as …

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