Clayton Deighan

Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer

Camille V. Trinidad, Harsh B. Pathak, Shibo Cheng, Shin‐Cheng Tzeng et autres

High grade serous ovarian carcinoma (HGSOC) accounts for ~ 70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. Since most HGSOCs typically arise from the fallopian …

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Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer

Camille V. Trinidad, Harsh B. Pathak, Shin‐Cheng Tzeng, Rashna Madan et autres

High grade serous ovarian carcinoma (HGSOC) accounts for ~ 70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. Since most HGSOCs typically arise from the fallopian …

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Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit

Robert G. Kowalski, Aurélie Ledreux, John Violette, Robert Neumann et autres

BACKGROUND: Neuroinflammation is ubiquitous in acute stroke and worsens outcome. However, the precise timing of the inflammatory response is unknown, hindering the design of acute anti-inflammatory therapeutic interventions. We sought to identify the onset of the neuroinflammatory cascade using a mobile stroke …

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Abstract 17: Ultra-early Activation Of Neuroinflammatory Cascade Following Acute Stroke: Plasma And Extracellular Vesicle Biomarkers From A Mobile Stroke Unit

Robert G. Kowalski, Aurélie Ledreux, John Violette, Robert Neumann et autres

Background: Neuroinflammation is ubiquitous in acute stroke and worsens outcome. However, the precise timing of the inflammatory response is unknown, hindering the design of acute anti-inflammatory therapeutic interventions. We used a mobile stroke unit (MSU) to identify the onset of the neuroinflammatory …

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Revealing the presence of tear extracellular vesicles in Keratoconus

Brenna S. Hefley, Clayton Deighan, Brenda Vasini, Asher Khan et autres

Extracellular vesicles (EVs) are lipid-bound vesicles that originate from the endosomal system or budded off from the plasma membrane. EVs are involved in cell-cell communication via transporting DNA, RNA, and proteins from one cell to another. Tear EVs (tEVs) have been reported …

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Single-Particle Interferometric Reflectance Imaging Characterization of Individual Extracellular Vesicles and Population Dynamics

Fengyan Deng, Anamika Ratri, Clayton Deighan, George G. Daaboul et autres

Extracellular vesicles (EVs) are nanometer-sized vesicles with a lipid bilayer that are secreted by most cells. EVs carry a multitude of different biological molecules, including protein, lipid, DNA, and RNA, and are postulated to facilitate cell-to-cell communication in diverse tissues and organs. …

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Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo

Andrea Estrada, Zackary J. Valenti, Gabriella Hehn, Adam J. Amorese et autres

Extracellular vesicles (EVs) are biomarkers and modifiers of human disease. EVs secreted by insulin-responsive tissues like skeletal muscle (SkM) and white adipose tissue (WAT) contribute to metabolic health and disease but the relative abundance of EVs from these tissues has not been …

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WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1

Meizhang Li, Rupal P. Soder, Sunil Abhyankar, Haitham Abdelhakim et autres

Both mesenchymal stem cells (MSCs) and their corresponding small extracellular vesicles (sEVs, commonly referred to as exosomes) share similar immunomodulatory properties that are potentially beneficial for the treatment of acute graft versus host disease (aGvHD). We report that clinical grade Wharton's Jelly-derived …

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AJP-Cell Estrada et al. Supplemental Data

Andrea Estrada, Zackary J. Valenti, Gabriella Hehn, Adam J. Amorese et autres

Supplemental data demonstrating that electrical stimulation of skeletal muscle does not increase EV secretion ex vivo.

Diverse Populations of Extracellular Vesicles with Opposite Functions during Herpes Simplex Virus 1 Infection

Christos Dogrammatzis, Shadia Saleh, Clayton Deighan, Maria Kalamvoki

Extracellular vesicles mediate cell-to-cell communication and convey messages important for cell homeostasis. Pathways of EV biogenesis are often hijacked by pathogens to facilitate their dissemination and to establish a favorable microenvironment for the infection. We have previously shown that HSV-1 infection alters …

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Multiparameter Evaluation of the Heterogeneity of Circulating Tumor Cells Using Integrated RNA In Situ Hybridization and Immunocytochemical Analysis

Yongqi Wu, Kyoung‐Joo Jenny Park, Clayton Deighan, Peter Amaya et autres

Circulating tumor cells (CTCs) are routinely identified as cytokeratin (CK) positive, epithelial cell adhesion molecule (EpCAM) positive and CD45 negative, and are enriched based on EpCAM. However, there are a number of methodological challenges regarding both isolation and characterization of these rare …

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Analyzing the miRNA content of extracellular vesicles by fluorescence nanoparticle tracking

Scott A. Baldwin, Clayton Deighan, Elga Bandeira, Kwang Joo Kwak et autres

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