Shaobin Jia

Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury

Xuehu Zhang, Aoqin Gu, Lirong Zhou, Yuru Ma et autres

BACKGROUND: Myocardial ischemia-reperfusion injury (I/R) significantly exacerbates cardiomyocyte damage post-recanalization therapy in acute myocardial infarction. Pyroptosis and the NLRP3 inflammasome are crucial in I/R, yet the precise mechanism remains unclear. MATERIALS AND METHODS: Transcriptomics, proteomics, and single-cell transcriptomics were employed to examine …

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Identification of UAP1 as a Molecular Link Between NAFLD and Heart Failure: Multi-Omics and Experimental Validation

Wei Gong, X W Li, Ru Yan, Zhou Zhenggang et autres

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Differential impact of lipid levels on the association between homocysteine and new-onset atrial fibrillation in acute myocardial infarction patients

Peng Wu, Juan Ma, Mohan Wang, Baozhen Zhu et autres

BACKGROUND: Homocysteine (Hcy) and dyslipidemia are both established risk factors for cardiovascular disease. However, their interaction in the development of new-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI)-especially across different baseline LDL-C levels-is not well-understood. METHODS: This retrospective cohort study included …

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Predictive Factors and Clinical Outcomes of Stent Malapposition in Calcified Lesions After PCI: A Retrospective Observational Study Based on OCT Assessment

Qinning Zhang, Ru Yan, Baozhen Zhu, Guangzhi Cong et autres

Background: Stent malapposition (SM) remains a significant challenge in percutaneous coronary intervention (PCI), particularly in cases involving calcified coronary lesions. However, the predictors of SM and their relationship with clinical outcomes remains unclear. This study aims to identify the predictors of SM …

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Corrigendum to “PCSK9 inhibition mitigates vulnerable plaque formation induced by hyperhomocysteinemia through regulating lipid metabolism and inflammation” [Biochem. Pharmacol. 239 (2025) 117031]

Ping Jin, Juan Ma, Peng Wu, Ru Yan et autres

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The relationship between homocysteine and new-onset atrial fibrillation in patients with acute myocardial infarction

Ping Jin, Peng Wu, Juan Ma, Yitong Bian et autres

OBJECTIVE: Elevated homocysteine (Hcy) are linked to an augmented risk of cardiovascular disorders. However, relationship between Hcy and in-hospital new-onset atrial fibrillation (NOAF) among patients experiencing acute myocardial infarction (AMI) remains uncertain. This study investigated the association between Hcy and incidence of …

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Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality among cardiovascular-kidney-metabolic syndrome: a national cross-sectional study

Peng Wu, Zhenghui Huang, Juan Ma, Baozhen Zhu et autres

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PCSK9 inhibition mitigates vulnerable plaque formation induced by hyperhomocysteinemia through regulating lipid metabolism and inflammation

Ping Jin, Juan Ma, Peng Wu, Yitong Bian et autres

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The Impact of Malnutrition on Perioperative Ischemic Stroke in Transcatheter Aortic Valve Replacement (TAVR): A Retrospective Cohort Study of the National Inpatient Sample

Guangzhi Cong, Xueping Ma, Bo Shi, Congyan Ye et autres

ABSTRACT Background and Aims Ischemic stroke is a serious risk for patients undergoing transcatheter aortic valve replacement (TAVR). The relationship between malnutrition and post‐TAVR ischemic stroke remains unclear. This study investigates this association using the National Inpatient Sample (NIS) data. Methods A …

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Lactobacillus rhamnosus GG ameliorates atherosclerosis via suppression of oxidative stress and inflammation by reshaping the gut microbiota

Yajuan Liu, Zhixia Bai, Ru Yan, Junbai Ma et autres

OBJECTIVE: With growing awareness of probiotics' benefits, more studies are exploring their efficacy and mechanisms in reducing atherosclerosis (AS). This study aimed to investigate the potential therapeutic effects of Lactobacillus rhamnosus GG (LGG) on atherosclerotic mice and underlying mechanisms. DESIGN: and C57BL/6J …

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Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers

Ping Jin, Juan Ma, Peng Wu, Yitong Bian et autres

BACKGROUND: mice. These findings suggest complex roles for both Hcy and PCSK9 in AS. This study investigated the mutual mediating influence of Hcy together with PCSK9 on coronary lesion severity among individuals diagnosed with acute coronary syndrome (ACS), focusing on their interplay …

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Sirolimus-Eluting Iron Bioresorbable Scaffolds Versus Everolimus-Eluting Stents in Patients with Coronary Artery Disease: A Single-Blind, Randomised Trial (IRONMAN II)

Runlin Gao, Lei Song, Guosheng Fu, Changdong Guan et autres

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