Guangzhi Cong

Trem2 regulates macrophage phenotype via the JAK2/STAT3 signaling pathway to ameliorate ventricular remodeling after acute myocardial infarction

Zefeng He, Jing Feng, Ru Yan, Peng Wu et autres

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Sex Differences in Acute Ischemic Stroke After Transcatheter Aortic Valve Implantation in Chronic Inflammatory Disease: National Inpatient Study

Qinning Zhang, Ru Yan, Guangzhi Cong, Shaobin Jia

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Combined Effect of Low-Density Lipoprotein Cholesterol and Homocysteine on Major Adverse Cardiovascular Events in Coronary Heart Disease: A Retrospective Cohort Study

Baozhen Zhu, Xingyu Luo, Peng Wu, Yuru Ma et autres

Background: Residual cardiovascular risk remains substantial despite aggressive low-density lipoprotein cholesterol (LDL-C) lowering in coronary heart disease (CHD). Consequently, this elevated risk has spurred the search for non-lipid targets, such as homocysteine (HCY). However, the combined effect of HCY with LDL-C and …

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Impact of lymphoma on clinical outcomes during hospitalization for acute myocardial infarction: a retrospective cohort study from the National Inpatient Sample Database (2016–2021)

Israel Gitangaza, Abdul Rehman, Bo Shi, Xueping Ma et autres

Background: Lymphoma increases cardiovascular risk, but its effects on ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) management and outcomes remain unclear. This study compared in-hospital outcomes and treatment strategies between acute myocardial infarction patients with and without lymphoma. Methods: We …

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In-hospital outcomes and temporal analysis of paralyzed patients with acute myocardial infarction undergoing percutaneous coronary intervention

Haohong Qi, Mingzhi Cui, Ting Zhang (102583), Xueping Ma et autres

This study aimed to explore the association between two major etiologies of paralysis and the in-hospital outcomes of patients with acute myocardial infarction (AMI) who had undergone percutaneous coronary intervention (PCI). We retrieved AMI patients undergoing PCI from the National Inpatient Sample …

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Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury

Xuehu Zhang, Aoqin Gu, Lirong Zhou, Yuru Ma et autres

BACKGROUND: Myocardial ischemia-reperfusion injury (I/R) significantly exacerbates cardiomyocyte damage post-recanalization therapy in acute myocardial infarction. Pyroptosis and the NLRP3 inflammasome are crucial in I/R, yet the precise mechanism remains unclear. MATERIALS AND METHODS: Transcriptomics, proteomics, and single-cell transcriptomics were employed to examine …

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Impact of Early Versus Delayed Permanent Pacemaker Implantation on Clinical Outcomes in Patients With Third‐Degree Atrioventricular Block After Transcatheter Aortic Valve Replacement: A National Inpatient Sample Analysis

B. He, Guangzhi Cong, Congyan Ye, Bo Shi et autres

Abstract Background Third-degree atrioventricular (AV) block following transcatheter aortic valve replacement (TAVR) often necessitates permanent pacemaker (PPM) implantation. However, the impact of PPM timing on clinical outcomes remains unclear. Methods Utilizing the National Inpatient Sample (2016–2021), we identified third degree AV block …

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The association between APOA1 levels and long-term outcomes in H-type hypertension with acute myocardial infarction patients: A retrospective cohort study

Baozhen Zhu, Peng Wu, Zefeng He, Juan Ma et autres

H-type hypertension, characterized by concomitant hypertension and hyperhomocysteinemia (HHcy), is associated with heightened cardiovascular risk. Despite emerging evidence implicating apolipoprotein A1 (APOA1) in atherosclerotic processes, its prognostic value in acute myocardial infarction (AMI) patients with H-type hypertension remains underexplored.We conducted multivariable-adjusted cox …

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Association between Atrial Fibrillation and the risk of New-Onset Left bundle branch block following Transcatheter Mitral Valve Replacement: a retrospective analysis of the National Inpatient Sample

Qing Chen, Ying Cui, Ying Guo, Lin He et autres

Abstract Background Transcatheter mitral valve replacement (TMVR) offers an alternative for high-risk patients with mitral valve disease. Atrial fibrillation (AF) frequently coexists with mitral valve disease, while new-onset left bundle branch block (NLBBB) following transcatheter valve interventions may adversely affect cardiac function …

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Predictive Factors and Clinical Outcomes of Stent Malapposition in Calcified Lesions After PCI: A Retrospective Observational Study Based on OCT Assessment

Qinning Zhang, Ru Yan, Baozhen Zhu, Guangzhi Cong et autres

Background: Stent malapposition (SM) remains a significant challenge in percutaneous coronary intervention (PCI), particularly in cases involving calcified coronary lesions. However, the predictors of SM and their relationship with clinical outcomes remains unclear. This study aims to identify the predictors of SM …

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Impact of Urinary Tract Infections on In-Hospital Outcomes in Acute Myocardial Infarction: Insights from the National Inpatient Sample (2016-2021)

Abdul Rehman, Israel Gitangaza, Guangzhi Cong, Shaobin Jia et autres

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Risk of acute ischemic stroke with early versus late initiation of mechanical circulatory support in hospitalizations with acute myocardial infarction complicated by cardiogenic shock: a propensity-matched analysis

Rui Yan, Jie Yang, Bo Shi, Congyan Ye et autres

BACKGROUND: Mechanical circulatory support (MCS) devices have been widely used for managing acute myocardial infarction complicated by cardiogenic shock (AMI-CS). However, their use additionally elevates acute ischemic stroke (AIS) risk. There is insufficient data on the risk of AIS associated with early …

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