Nathan Langer

Patient-reported outcomes from the BESPOKE CRC study.

Pashtoon Murtaza Kasi, Samuel Rivero-Hinojosa, Vasily N. Aushev, Nathan Langer et autres

54 Background: BESPOKE CRC is a multicenter, prospective, observational study that investigates the clinical utility of ctDNA for optimal use of adjuvant chemotherapy and early detection of recurrence in patients (pts) with surgically resected CRC. The perceived utility and impact ctDNA testing …

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Circulating tumor DNA (ctDNA) for informing adjuvant chemotherapy (ACT) in stage II/III colorectal cancer (CRC): Interim analysis of BESPOKE CRC study.

Pashtoon Murtaza Kasi, Vasily N. Aushev, Joe Ensor, Nathan Langer et autres

9 Background: ctDNA-based post-surgical detection of molecular residual disease (MRD) is known to be predictive of a high risk of recurrence. Here, we report the first results of BESPOKE CRC, a multicenter, prospective, observational study evaluating the ability of a tumor-informed ctDNA …

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Managing Severe Aortic Stenosis in the COVID-19 Era

Varsha K. Tanguturi, Brian R. Lindman, Philippe Pîbarot, Jonathan Passeri et autres

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Intracardiac or intrapulmonary shunts were present in at least 35% of adults with homozygous sickle cell disease followed in an outpatient clinic

Bryan C. Hambley, Rania Abdul Rahman, M.A. Reback, Mary Ann O’Riordan et autres

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Right-to-Left Shunts Are Unexpectedly Common in Adults with HbSS

Bryan C. Hambley, Rania Abdul Rahman, Mary Ann O’Riordan, Nathan Langer et autres

Abstract INTRODUCTION: Patients with homozygous sickle cell anemia (SCA) have frequent cardiopulmonary complications. The clinical prevalence and consequences of intracardiac or intrapulmonary right-to-left shunts in SCA are unknown. Here we report a retrospective examination of this complication, and clinical and laboratory correlates …

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Nocturnal hemoglobin desaturation is associated with reticulocytosis in adults with sickle cell disease and is independent of obstructive sleep apnea

Seth J. Rotz, Mary Ann O’Riordan, Ceonne Kim, Nathan Langer et autres

To the Editor: Adults with sickle cell disease (SCD) experience significant cumulative organ damage. The prevalence of obstructive sleep apnea (OSA) in symptomatic adults with SCD has been reported to be as high as 44% 1. OSA may be deleterious in SCD …

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Nocturnal Hypoxemia (not sleep apnea) May Drive Reticulocytosis in Sickle Cell Disease

Jane A. Little, Seth Rotz, Ceonne Kim, MaryAnn O’Riordan et autres

Abstract Introduction: Obstructive sleep apnea is a ventilatory defect that affects up to 10% of children with sickle cell disease (SCD). Sleep apnea has been implicated in cardiovascular disease in non-SCD adults and in cerebrovascular disease in children with SCD. In addition, …

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Right-To-Left Shunts (Extra-Cardiac Arterial-Venous Malformations) Are Highly Common In Adults With Sickle Cell Disease

Nathan Langer, MaryAnn O’Riordan, Santosh Rao, Jane A. Little et autres

Abstract Introduction Cardiopulmonary complications are a major cause of morbidity and mortality in sickle cell disease (SCD) as shown by worse prognosis in patients who have experienced acute chest syndrome or who have an elevated tricuspid regurgitant jet velocity (TRV) on echocardiogram …

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Serum cobalamin concentrations in healthy cats and cats with non‐alimentary tract illness in Australia

PM Barron, John T. Mackie, N. Evans, Nathan Langer

OBJECTIVE: To determine a reference range for serum cobalamin concentration in healthy cats in Australia using a chemiluminescent enzyme immunoassay and to prospectively investigate the prevalence of hypocobalaminaemia in cats with non-alimentary tract disease. DESIGN: Prospective study measuring serum cobalamin concentrations in …

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