Tracy Dalton

Use of nucleic acid amplification testing for rapid detection of Mycobacterium tuberculosis complex among U.S. tuberculosis patients from 2011‒2017

Varsha S. Kumar, Tracy Dalton, Lori Armstrong, Amy Whitesell et autres

Background: complex directly from clinical specimens, providing valuable results for those evaluated for tuberculosis. Methods: We analyzed characteristics of cases with NAA testing performed, compared cases with positive and negative NAA test results, and calculated turnaround time and time to treatment for …

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Towards Unified Data Exchange Formats for Reporting Molecular Drug Susceptibility Testing

Wilfred Bonney, Sandy F. Price, Swapna Abhyankar, Riki Merrick et autres

BACKGROUND: With the rapid development of new advanced molecular detection methods, identification of new genetic mutations conferring pathogen resistance to an ever-growing variety of antimicrobial substances will generate massive genomic datasets for public health and clinical laboratories. Keeping up with specialized standard …

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Molecular Evaluation of Fluoroquinolone Resistance in Serial Mycobacterium tuberculosis Isolates from Individuals Diagnosed with Multidrug-Resistant Tuberculosis

Melisa J. Willby, Paige Chopra, Darrin Lemmer, Katherine A. Klein et autres

group patients had isolates with FQ resistance alleles prior to changes to the FQ component of their treatment. Unlike the individuals treated initially with other FQs, none of the 21 individuals treated initially with levofloxacin developed genotypic or phenotypic FQ resistance, although …

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Isoniazid and Rifampin-Resistance Mutations Associated With Resistance to Second-Line Drugs and With Sputum Culture Conversion

Eleanor S. Click, Ekaterina V. Kurbatova, Heather Alexander, Tracy Dalton et autres

BACKGROUND: Mutations in the genes inhA, katG, and rpoB confer resistance to anti-tuberculosis (TB) drugs isoniazid and rifampin. We questioned whether specific mutations in these genes were associated with different clinical and microbiological characteristics. METHODS: In a multicountry prospective cohort study of …

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Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline

Payam Nahid, Sundari Mase, Giovanni Battista Migliori, Giovanni Sotgiu et autres

Abstract Background The American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America jointly sponsored this new practice guideline on the treatment of drug-resistant tuberculosis (DR-TB). The document includes recommendations on the treatment …

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Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations Not Detectable by Common Molecular Tests

Justin L. Kandler, Alexandra Mercante, Tracy Dalton, Matthew Ezewudo et autres

mutations conferred resistance to INH at a MIC of ≥0.25 μg/ml and should be added to the list of INH resistance determinants targeted by molecular diagnostic assays. We conclude that WGS is a useful tool for detecting uncommon INH resistance mutations that …

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Validation of novel Mycobacterium tuberculosis isoniazid resistance mutations not detectable by common molecular tests

Justin L. Kandler, Alexandra Mercante, Tracy Dalton, Matthew Ezewudo et autres

Abstract Resistance to the first-line anti-tuberculosis (TB) drug, isoniazid (INH), is widespread, and the mechanism of resistance is unknown in approximately 15% of INH-resistant (INH-R) strains. To improve molecular detection of INH-R TB, we used whole genome sequencing (WGS) to analyze 52 …

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Initial Public Health Laboratory Response After Hurricane Maria — Puerto Rico, 2017

Jeniffer Concepción‐Acevedo, Anita Patel, Carolina Luna-Pinto, Rafael González Peña et autres

Hurricane Maria made landfall in Puerto Rico on September 20, 2017, causing major damage to infrastructure and severely limiting access to potable water, electric power, transportation, and communications. Public services that were affected included operations of the Puerto Rico Department of Health …

The Use of a Shared Services Model for Mycobacteriology Testing: Lessons Learned

Cortney Stafford, Robyn Atkinson-Dunn, Sarah N. Buss, Tracy Dalton et autres

OBJECTIVES: Public health laboratories (PHLs) provide essential services in the diagnosis and surveillance of diseases of public health concern, such as tuberculosis. Maintaining access to high-quality laboratory testing is critical to continued disease detection and decline of tuberculosis cases in the United …

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Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: a mathematical modelling study

Aditya Sharma, Andrew Hill, Ekaterina V. Kurbatova, Martie van der Walt et autres

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Designing Shifts to Position Teacher as Designer of Learning

Stephanie Bartlett, Erin Quinn, Tracy Dalton, Steve Clark

Design the Shift (DTS) is an iterative professional learning series for educators, immersing them as learners with an emphasis on design thinking mindsets. Using DTS as the context, we juxtapose field notes, observations, participant data, and reflection with the Teaching Effectiveness Framework …

Susceptibilities of MDR Mycobacterium tuberculosis isolates to unconventional drugs compared with their reported pharmacokinetic/pharmacodynamic parameters

Joseph S. Cavanaugh, Ruwen Jou, Mei-Hua Wu, Tracy Dalton et autres

Background: The second-line drugs recommended to treat drug-resistant TB are toxic, expensive and difficult to procure. Given increasing resistance, the need for additional anti-TB drugs has become more urgent. But new drugs take time to develop and are expensive. Some commercially available …

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